PloS one · 2008
The mych gene is required for neural crest survival during zebrafish development.
СтатьяResearch Support, N.I.H., IntramuralНазвание и аннотация: Перевод в очереди
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Hong Sung-Kook, Tsang Michael, Dawid Igor B
Аннотация
BACKGROUND: Among Myc family genes, c-Myc is known to have a role in neural crest specification in Xenopus and in craniofacial development in the mouse. There is no information on the function of other Myc genes in neural crest development, or about any developmental role of zebrafish Myc genes.
PRINCIPAL FINDINGS: We isolated the zebrafish mych (myc homologue) gene. Knockdown of mych leads to severe defects in craniofacial development and in certain other tissues including the eye. These phenotypes appear to be caused by cell death in the neural crest and in the eye field in the anterior brain.
SIGNIFICANCE: Mych is a novel factor required for neural crest cell survival in zebrafish.
PRINCIPAL FINDINGS: We isolated the zebrafish mych (myc homologue) gene. Knockdown of mych leads to severe defects in craniofacial development and in certain other tissues including the eye. These phenotypes appear to be caused by cell death in the neural crest and in the eye field in the anterior brain.
SIGNIFICANCE: Mych is a novel factor required for neural crest cell survival in zebrafish.
Предметные рубрики MeSH
Amino Acid SequenceAnimalsBiomarkersBody PatterningBrainBranchial RegionCell DeathDNA, ComplementaryEmbryo, NonmammalianGene Expression Regulation, DevelopmentalMolecular Sequence DataNeural CrestNeural PlateOligonucleotides, AntisensePhenotypeSequence Analysis, ProteinSomitesTranscription FactorsZebrafishZebrafish Proteins