Gut microbes · 2024
Fecal transplant from vaginally seeded infants decreases intraabdominal adiposity in mice.
СтатьяРандомизированное исследованиеResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Namasivayam Sivaranjani, Tilves Curtis, Ding Hua, Wu Shaoguang, Domingue Jada C, Ruiz-Bedoya Camilo, Shah Ankit, Bohrnsen Eric, Schwarz Benjamin, Bacorn Mickayla, Chen Qing, Levy Shira, Dominguez Bello Maria Gloria, Jain Sanjay K, Sears Cynthia L, Mueller Noel T, Hourigan Suchitra K
Аннотация
Exposing C-section infants to the maternal vaginal microbiome, coined "vaginal seeding", partially restores microbial colonization. However, whether vaginal seeding decreases metabolic disease risk is unknown. Therefore, we assessed the effect of vaginal seeding of human infants on adiposity in a murine model. Germ-free mice were colonized with transitional stool from human infants who received vaginal seeding or control (placebo) seeding in a double-blind randomized trial. There was a reduction in intraabdominal adipose tissue (IAAT) volume in male mice that received stool from vaginally seeded infants compared to control infants. Higher levels of isoleucine and lower levels of nucleic acid metabolites were observed in controls and correlated with increased IAAT. This suggests that early changes in the gut microbiome and metabolome caused by vaginal seeding have a positive impact on metabolic health.