CMR Findings in the Long-Term Outcomes After Multisystem Inflammatory Syndrome in Children (MUSIC) Study.
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Lang Sean M, Truong Dongngan T, Powell Andrew J, Kazlova Valiantsina, Newburger Jane W, Awerbach Jordan D, Binka Edem, Bradford Tamara T, Cartoski Mark, Cheng Andrew, DiLorenzo Michael P, Dionne Audrey, Dorfman Adam L, Elias Matthew D, Garuba Olukayode, Gerardin Jennifer F, Hasbani Keren, Jone Pei-Ni, Lam Christopher Z, Misra Nilanjana, Morgan Lerraughn M, Nutting Arni, Patel Jyoti K, Robinson Joshua D, Schuchardt Eleanor L, Sexson Tejtel Kristen, Singh Gautam K, Slesnick Timothy C, Trachtenberg Felicia, Taylor Michael D, MUSIC Study Investigators
Аннотация
METHODS: In this observational cohort study, comprising 32 centers in North America, CMR studies were analyzed by a core laboratory to assess ventricular volumetric data, tissue characterization, and coronary involvement.
RESULTS: A total of 263 CMRs from 255 patients with Multisystem Inflammatory Syndrome in Children were analyzed. The mean patient age was 11.4±4.4 years. Most studies were performed at 3 months (33%) or 6 months (45%) after hospitalization. Left ventricular dysfunction was present in 17 (6.7%) of the first CMRs and was never worse than mild. Dysfunction was observed in 4/7 (57%) patients at admission, 5/87 (6.9%) patients at 3 months, and 6/129 (4.6%) patients imaged either at 6 months or 1 year post-hospitalization. Late gadolinium enhancement was present in 2 (0.8%) patients, 1 at 3 months and another at 6 months following hospitalization. Coronary artery dilation was present in 13 of the 174 (7.5%) patients. Nine patients met the Lake Louise criteria for myocarditis (3.5%) at the time of CMR.
CONCLUSIONS: In this largest published multiinstitutional longitudinal CMR evaluation of confirmed patients with Multisystem Inflammatory Syndrome in Children, the prevalence of ventricular dysfunction and myocardial tissue characterization abnormalities on medium-term follow-up was low. However, a small number of patients had mild residual abnormalities at 6 months and 1 year following hospitalization.
REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05287412.