Electrophoresis patterns of proteinuria in various renal diseases of childhood.

The purpose of the study was to assess electrophoresis patterns of proteinuria in children with different renal diseases. The study comprised 52 children (30 boys and 22 girls) aged 2-18 years hospitalized in the Department of Nephrology, University Children's Hospital, Lublin. Nephrotic syndrome, glomerulonephritis and isolated proteinuria were diagnosed in 26, 11 and 15 children, respectively. Electrophoresis of urinary proteins was performed using the system SEBIA-Hydragel Proteinuria. Steroid-responsive, steroid-resistant and steroid-dependent nephrotic syndromes were characterized by glomerular selective proteinuria in 76%, 40% and 12.5% of children, respectively. In other nephrotic children glomerular nonselective proteinuria was identified. Selective glomerular proteinuria was found in 45.5% of children with glomerulonephritis. In this group glomerular nonselective proteinuria and mixed proteinuria were diagnosed in 36.4% and 18.1% of children, respectively. In the majority of children with isolated proteinuria (66,7%) nonselective pattern was revealed. In this group glomerular selective proteinuria and mixed proteinuria were observed in 13.3% and 20% of children, respectively.