A prospective study on long-term trace metal accumulation in hair: Is there any difference between minimally invasive repair of pectus excavatum and carinatum?

BACKGROUND: To date, there is no study about trace metal level increases in hair after stainless steel pectus bar implantation. We aimed to determine whether there was any significant increase in the levels of trace metals in the hair of children who underwent minimally invasive repair of pectus excavatum (MIRPE) and minimally invasive repair of pectus carinatum (MIRPC).

MATERIALS AND METHODS: In this prospective study, we collected the data of 223 patients who underwent MIRPE and MIRPC between November 2013 and August 2020. The levels of main components of the stainless steel pectus bar ("PES", Medxpert GmbH, Escbach, Germany) namely Cr, Fe, Ni, and Mo in hair were analyzed. The study involved two study groups: A group of patients who underwent MIRPE with a single bar (n = 112) and a group of patients who underwent MIRPC (n = 71). Both groups were analyzed in two different timelines: A group of consecutive patients prior to bar implantation and a group of the same patients who underwent bar removal after a mean time of 34.6 ± 5.1 months.

RESULTS: Statistically significant increases in all studied trace metal levels were observed in the single-bar MIRPE group. In the MIRPC group, the accumulation of studied trace metals was no statistically significant. The double-bar MIRPE group had higher trace metal increase rates compared to single-bar MIRPE group (p>0.05).

CONCLUSION: In our study; increases in iron, chrome, nickel and molybdenum levels were observed in both MIRPE and MIRPC patients by hair trace metal analysis; but these increases were statistically significant in only MIRPE group.