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DOI 10.1126/sciadv.adr2084

Медицинская библиотека · Science advances · 2024

Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium.

Wang Siwen, Casey Emma, Sordillo Joanne, Aguilar-Lacasaña Sofía, Morales Berstein Fernanda, Biedrzycki Richard J, Brescianini Sonia, Chen Su, Hough Amy, Isaevska Elena, Kim Woo Jin, Lecorguillé Marion, Li Sebastian Shaobo, Page Christian M, Park Jaehyun, Röder Stefan, Salontaji Kristina, Santorelli Gillian, Sun Yidan, Won Sungho, Zillich Eric, Zillich Lea, Annesi-Maesano Isabella, Arshad S Hasan, Bustamante Mariona, Cecil Charlotte A M, Elliott Hannah R, Ewart Susan, Felix Janine F, Gagliardi Luigi, Håberg Siri E, Herberth Gunda, Heude Barbara, Holloway John W, Huels Anke, Karmaus Wilfried, Koppelman Gerard H, London Stephanie J, Mumford Sunni L, Nisticò Lorenza, Popovic Maja, Rusconi Franca, Schisterman Enrique F, Stein Dan J, Send Tabea, Tiemeier Henning, Vonk Judith M, Vrijheid Martine, Wiemels Joseph Leo, Witt Stephanie H, Wright John, Yeung Edwina H, Zar Heather J, Zenclussen Ana C, Zhang Hongmei, Chavarro Jorge E, Hivert Marie-France

СтатьяМетаанализПоддержка NIH: внешняя программаПеревод в очереди

Аннотация

Children born via cesarean delivery have a higher risk of metabolic, immunological, and neurodevelopmental disorders compared to those born via vaginal delivery, although mechanisms remain unclear. We conducted a meta-analysis of epigenome-wide association studies to examine the associations between delivery mode and blood DNA methylation at birth and its persistence in early childhood. Participants were from 19 pregnancy cohorts (9833 term newborns) and 6 pediatric cohorts (2429 children aged 6 to 10 years). We identified six CpGs in cord blood associated with cesarean delivery (effect size range: 0.4 to 0.7%, P < 1.0 × 10-7): MAP2K2 (cg19423175), LIM2 (cg01500140), CNP (cg13917614), BLM (cg18247172), RASA3 (cg22348356), and RUNX3 (cg20674490), independent of cell proportions and other confounders. In childhood, none of these CpGs were associated with cesarean delivery, and no additional CpGs were identified. Delivery mode was associated with cell proportions at birth but not in childhood. Further research is needed to elucidate cesarean delivery's molecular influence on offspring health.

Для цитирования: Wang Siwen, Casey Emma, Sordillo Joanne, Aguilar-Lacasaña Sofía, Morales Berstein Fernanda, Biedrzycki Richard J, Brescianini Sonia, Chen Su, Hough Amy, Isaevska Elena, Kim Woo Jin, Lecorguillé Marion, Li Sebastian Shaobo, Page Christian M, Park Jaehyun, Röder Stefan, Salontaji Kristina, Santorelli Gillian, Sun Yidan, Won Sungho, Zillich Eric, Zillich Lea, Annesi-Maesano Isabella, Arshad S Hasan, Bustamante Mariona, Cecil Charlotte A M, Elliott Hannah R, Ewart Susan, Felix Janine F, Gagliardi Luigi, Håberg Siri E, Herberth Gunda, Heude Barbara, Holloway John W, Huels Anke, Karmaus Wilfried, Koppelman Gerard H, London Stephanie J, Mumford Sunni L, Nisticò Lorenza, Popovic Maja, Rusconi Franca, Schisterman Enrique F, Stein Dan J, Send Tabea, Tiemeier Henning, Vonk Judith M, Vrijheid Martine, Wiemels Joseph Leo, Witt Stephanie H, Wright John, Yeung Edwina H, Zar Heather J, Zenclussen Ana C, Zhang Hongmei, Chavarro Jorge E, Hivert Marie-France. Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium.. Science advances. 2024. DOI: 10.1126/sciadv.adr2084.

Предметные рубрики MeSH

HumansDNA MethylationFemalePregnancyCesarean SectionChildEpigenesis, GeneticInfant, NewbornCpG IslandsGenome-Wide Association StudyFetal Blood
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