Ocular immunology and inflammation · 2011
Bilateral microbial keratitis in highly active antiretroviral therapy-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: a case series.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Sachdev Ritika, Bansal Shubha, Sinha Rajesh, Sharma Namrata, Titiyal Jeewan S
Аннотация
PURPOSE: To report three cases of bilateral microbial keratitis in eyes with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) induced by highly active antiretroviral therapy (HAART) in patients of acquired immune deficiency syndrome (AIDS).
METHODS: A case series.
RESULTS: A detailed clinical examination and systemic review of all the three patients on HAART was performed. While one manifested with the more severe variant of TEN, two of these patients presented with SJS with ocular involvement. Despite withdrawal of nevirapine, the ocular surface disorder persisted. The entailing chronic epitheliopathy along with the compromised immune status led to the development of secondary microbial keratitis in all these cases.
CONCLUSIONS: The immune reconstitution occurring as a response to the antiretroviral therapy may potentially increase immunologically mediated diseases like SJS and TEN, which in turn may predispose the eye to develop corneal ulcer.
METHODS: A case series.
RESULTS: A detailed clinical examination and systemic review of all the three patients on HAART was performed. While one manifested with the more severe variant of TEN, two of these patients presented with SJS with ocular involvement. Despite withdrawal of nevirapine, the ocular surface disorder persisted. The entailing chronic epitheliopathy along with the compromised immune status led to the development of secondary microbial keratitis in all these cases.
CONCLUSIONS: The immune reconstitution occurring as a response to the antiretroviral therapy may potentially increase immunologically mediated diseases like SJS and TEN, which in turn may predispose the eye to develop corneal ulcer.
Предметные рубрики MeSH
Acquired Immunodeficiency SyndromeAdultAmnionAnti-Bacterial AgentsAntiretroviral Therapy, Highly ActiveAza CompoundsBenzamidinesCarboxymethylcellulose SodiumCefazolinChlorhexidineCorneal UlcerDrug Therapy, CombinationFluoroquinolonesHumansMaleMiddle AgedMoxifloxacinPainQuinolinesStevens-Johnson SyndromeTobramycinTreatment OutcomeTropanesVisual Acuity