[Clinical manifestations of oligophrenia with fragile X syndrome in boys in the pre- and post-pubertal age].

Psychopathological, neurological and somatic manifestations of oligophrenia-with fragile X chromosome were investigated in 13 mentally retarded boys in prepuberty and in 9 such post-puberty++ patients. Age-related features of several psychopathological and somatic signs of the disease were revealed. The authors discuss the possibilities of clinical diagnosis of the disease and stress the importance of its early cytogenetical diagnosis in mentally retarded males.