Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2012
Urinary heme oxygenase-1 in children with congenital hydronephrosis due to ureteropelvic junction obstruction.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Li ZhenZhen, Liu XiangHua, Liu Shan, Gu ChaoHui, Tian FengYan, Wen JianGuo
Аннотация
CONTEXT: Heme oxygenase-1 (HO-1) is implicated to be correlated with renal function in oxidative stress.
OBJECTIVE: To determine whether urinary (u) HO-1 is associated with the progression of congenital obstructive hydronephrosis (HN).
METHODS: A total 50 children with HN (study group and control 1) and 30 healthy children were enrolled in this study.
RESULTS: The uHO-1/cr levels increased significantly and negatively correlated with split renal function in study group before and during surgery. One month after surgery, it decreased significantly.
CONCLUSION: Increased uHO-1 levels could be a potential biomarker for evaluating the progression of obstructive nephropathy.
OBJECTIVE: To determine whether urinary (u) HO-1 is associated with the progression of congenital obstructive hydronephrosis (HN).
METHODS: A total 50 children with HN (study group and control 1) and 30 healthy children were enrolled in this study.
RESULTS: The uHO-1/cr levels increased significantly and negatively correlated with split renal function in study group before and during surgery. One month after surgery, it decreased significantly.
CONCLUSION: Increased uHO-1 levels could be a potential biomarker for evaluating the progression of obstructive nephropathy.