Медицинская библиотека · Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2012

Urinary heme oxygenase-1 in children with congenital hydronephrosis due to ureteropelvic junction obstruction.

Li ZhenZhen, Liu XiangHua, Liu Shan, Gu ChaoHui, Tian FengYan, Wen JianGuo

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

CONTEXT: Heme oxygenase-1 (HO-1) is implicated to be correlated with renal function in oxidative stress.

OBJECTIVE

To determine whether urinary (u) HO-1 is associated with the progression of congenital obstructive hydronephrosis (HN).

METHODS

A total 50 children with HN (study group and control 1) and 30 healthy children were enrolled in this study.

RESULTS

The uHO-1/cr levels increased significantly and negatively correlated with split renal function in study group before and during surgery. One month after surgery, it decreased significantly.

CONCLUSION

Increased uHO-1 levels could be a potential biomarker for evaluating the progression of obstructive nephropathy.

Для цитирования: Li ZhenZhen, Liu XiangHua, Liu Shan, Gu ChaoHui, Tian FengYan, Wen JianGuo. Urinary heme oxygenase-1 in children with congenital hydronephrosis due to ureteropelvic junction obstruction.. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2012. DOI: 10.3109/1354750x.2012.689009.

Предметные рубрики MeSH

Biomarkers Case-Control Studies Child Child, Preschool Disease Progression Heme Oxygenase-1 Humans Hydronephrosis Infant Kidney Kidney Function Tests Male Prospective Studies ROC Curve Time Factors Ureteral Obstruction

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