Nonoperative Management of Multiple Hand Enchondromas in Ollier Disease With Progressive Ossification.

Ollier disease, or multiple enchondromatosis, has a distinct hallmark of disease variability and requires individualized patient treatment. This is a case report of an 18-year-old woman with Ollier disease isolated to her left hand that was treated nonoperatively for 8 years and followed with serial radiographs. Prognosis of Ollier disease limited to the bones of the hands is believed to be very good: only 12 cases of transformation to chondrosarcoma have been reported in the literature. However, a recent large retrospective multi-institutional study estimated a 15% lifetime risk of developing a malignancy at these locations.