Annals of oncology : official journal of the European Society for Medical Oncology · 2026
Multimodal artificial intelligence prediction of abiraterone efficacy in two STAMPEDE phase III trials of nonmetastatic very high-risk prostate cancer.
СтатьяКлиническое исследование III фазыРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Parker C T A, Huang H-C, Grist E, Mendes L, Yamashita R, Croucher D, Sachdeva A, Murphy L, Liu V Y T, Santos Vidal S, Todorovic T, Lall S, Goncalves M, Thakali S, Wingate A, Zakka L, Wetterskog D, Nowakowska K, Amos C L, Berney D M, Tran P T, Spratt D E, Sydes M R, Brown L C, Zhao S G, Nguyen P, Clarke N W, Sweeney C J, Stewart E L, Parmar M K B, Esteva A, James N D, Attard G, STAMPEDE Collaborators
Аннотация
BACKGROUND: Long-term androgen deprivation therapy (LT-ADT) with radiotherapy is standard-of-care for high-risk localized prostate cancer, with abiraterone added for clinically very high-risk disease. Given the potential toxicity and cost of abiraterone, a predictive biomarker to refine patient selection is needed. We evaluated a digital pathology multimodal artificial intelligence (MMAI) model, previously validated as a prognostic biomarker, for prediction of abiraterone benefit among nonmetastatic clinically very high-risk prostate cancer.
PATIENTS AND METHODS: MMAI scores were generated for patients enrolled in two sequential abiraterone trials (no shared controls) in the STAMPEDE (Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy) platform protocol (NCT00268476) using digital pathology images, prostate-specific antigen, tumor stage, and age. We applied the previously established 75th percentile threshold to classify patients as MMAI very high-risk or standard high-risk. The primary endpoint was metastasis-free survival (MFS). Treatment effects and risk estimates were obtained using Cox regression and Kaplan-Meier method, respectively. Prediction was assessed using a treatment-by-biomarker interaction Cox model.
RESULTS: In total, 1137 patients randomly assigned to LT-ADT (N = 583) or LT-ADT with abiraterone (N = 554) were included. The MMAI very high-risk group (N = 268) demonstrated significant MFS improvement from adding abiraterone [hazard ratio (HR) 0.47, 95% confidence interval (CI) 0.31-0.70], with 5-year MFS increasing from 62% (95% CI 54% to 70%) in LT-ADT to 81% (95% CI 74% to 88%) in LT-ADT with abiraterone. Limited abiraterone benefit was observed in the MMAI standard high-risk group (N = 869; HR 0.83, 95% CI 0.63-1.09), with a 5-year MFS of 82% (95% CI 78% to 85%) versus 84% (95% CI 80% to 87%, interaction P-value = 0.02). This differential effect was consistent in local node-negative and node-positive subgroups.
CONCLUSION: In this post hoc study of randomized clinical trial data, a locked digital pathology MMAI test displayed a strong prognostic association and predicted abiraterone efficacy in very high-risk, nonmetastatic prostate cancer. This biomarker could be implemented clinically to maximize benefit from treatment intensification while avoiding unnecessary toxicity.
PATIENTS AND METHODS: MMAI scores were generated for patients enrolled in two sequential abiraterone trials (no shared controls) in the STAMPEDE (Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy) platform protocol (NCT00268476) using digital pathology images, prostate-specific antigen, tumor stage, and age. We applied the previously established 75th percentile threshold to classify patients as MMAI very high-risk or standard high-risk. The primary endpoint was metastasis-free survival (MFS). Treatment effects and risk estimates were obtained using Cox regression and Kaplan-Meier method, respectively. Prediction was assessed using a treatment-by-biomarker interaction Cox model.
RESULTS: In total, 1137 patients randomly assigned to LT-ADT (N = 583) or LT-ADT with abiraterone (N = 554) were included. The MMAI very high-risk group (N = 268) demonstrated significant MFS improvement from adding abiraterone [hazard ratio (HR) 0.47, 95% confidence interval (CI) 0.31-0.70], with 5-year MFS increasing from 62% (95% CI 54% to 70%) in LT-ADT to 81% (95% CI 74% to 88%) in LT-ADT with abiraterone. Limited abiraterone benefit was observed in the MMAI standard high-risk group (N = 869; HR 0.83, 95% CI 0.63-1.09), with a 5-year MFS of 82% (95% CI 78% to 85%) versus 84% (95% CI 80% to 87%, interaction P-value = 0.02). This differential effect was consistent in local node-negative and node-positive subgroups.
CONCLUSION: In this post hoc study of randomized clinical trial data, a locked digital pathology MMAI test displayed a strong prognostic association and predicted abiraterone efficacy in very high-risk, nonmetastatic prostate cancer. This biomarker could be implemented clinically to maximize benefit from treatment intensification while avoiding unnecessary toxicity.