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DOI 10.1038/s41398-026-04189-x

Медицинская библиотека · Translational psychiatry · 2026

Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.

Sempach Lukas, Ulrich Sarah, Bauduin Stéphanie E E C, Bauer Jochen, Benedetti Francesco, Berger Klaus, Besteher Bianca, Bülow Robin, Connolly Colm G, Corruble Emmanuelle, Couvy-Duchesne Baptiste, Cullen Kathryn R, Dannlowski Udo, Davey Christopher G, Dima Danai, Dols Annemiek, Evans Jennifer W, Fu Cynthia, Fuentes-Claramonte Paola, Gonul Ali Saffet, Gotlib Ian H, Goya-Maldonado Roberto, Grabe Hans J, Groenewold Nynke A, Grotegerd Dominik, Gruber Oliver, Hahn Tim, Hamilton J Paul, Han Laura K M, Harrison Ben J, Hatton Sean N, Hermesdorf Marco, Hickie Ian B, Ho Tiffany C, Hubbert Julia M, Jahanshad Neda, Jamalabadi Hamidreza, Jamieson Alec J, Jurischka Christoph, Jüllig Antonia, Kamishikiryo Toshiharu, Kircher Tilo, Koopowitz Sheri-Michelle, Krämer Bernd, Kraus Anna, Krieger Judith, Krug Axel, Lagopoulos Jim, Li Meng, McIntosh Andrew, Meinert Susanne, Melloni Elisa M T, Mwangi Benson, Nenadic Igor, Ojha Amar, Okada Go, Oudega Mardien L, Penninx Brenda W J H, Poletti Sara, Pomarol-Clotet Edith, Portella Maria J, Reneman Liesbeth, Rodriguez-Cano Elena, Sacchet Matthew, Salvador Raymond, Schrantee Anouk, Shinzato Hotaka, Sim Kang, Slump Theresa M, Soares Jair C, Stein Dan J, Stein Frederike, Teutenberg Lea, Thomas-Odenthal Florian, Thomopoulos Sophia I, van der Wee Nic J A, van der Werff Steven J A, Völzke Henry, Walter Martin, Whalley Heather C, Whittle Sarah, Wittfeld Katharina, Wu Mon-Ju, Yang Tony T, Zarate Carlos, Zunta-Soares Giovana B, Thompson Paul M, Veltman Dick J, Pozzi Elena, Schmaal Lianne, Schmidt André

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Аннотация

The clinical and biological heterogeneity of major depressive disorder (MDD) may reflect the aggregation of different conditions with distinct pathologies under a single diagnostic label. Neuroanatomical heterogeneity in MDD was examined using a harmonized, age- and sex-matched sample from the ENIGMA MDD consortium (N = 5146; age range: 9-82 years; 64% female). Analyses of global neurostrucutral variability revealed greater cortical thickness heterogeneity in MDD compared with healthy controls (Cohen's d = -0.26). Regionally, increased variability in cortical thickness was most prominent in the cingulate (+6.1 to +6.6% more variation in MDD) and insular (+5.8%) cortices, as well as in the frontal (+5.7 to +6.8%) and temporal (+6.1 to +6.8%) lobes. Heterogeneity in cortical thickness was more pronounced among patients using antidepressant medication (Cohen's d = -0.39). Patient-specific analyses further showed that individuals with markedly increased cortical thickness variability (<5th percentile relative to the normative range) exhibited greater depressive symptom severity than those within the normative range (5th-95th percentile; Cohen's d = 0.19-0.36). Overall, the results indicate that neuroanatomical heterogeneity in MDD is primarily expressed in cortical thickness, offering refined insights into the neurobiological complexity of structural alterations associated with depression. These findings could guide future stratification efforts examining whether regionally confined changes in cortical thickness within areas of pronounced variability reflect clinically meaningful patient subgroups.

Для цитирования: Sempach Lukas, Ulrich Sarah, Bauduin Stéphanie E E C, Bauer Jochen, Benedetti Francesco, Berger Klaus, Besteher Bianca, Bülow Robin, Connolly Colm G, Corruble Emmanuelle, Couvy-Duchesne Baptiste, Cullen Kathryn R, Dannlowski Udo, Davey Christopher G, Dima Danai, Dols Annemiek, Evans Jennifer W, Fu Cynthia, Fuentes-Claramonte Paola, Gonul Ali Saffet, Gotlib Ian H, Goya-Maldonado Roberto, Grabe Hans J, Groenewold Nynke A, Grotegerd Dominik, Gruber Oliver, Hahn Tim, Hamilton J Paul, Han Laura K M, Harrison Ben J, Hatton Sean N, Hermesdorf Marco, Hickie Ian B, Ho Tiffany C, Hubbert Julia M, Jahanshad Neda, Jamalabadi Hamidreza, Jamieson Alec J, Jurischka Christoph, Jüllig Antonia, Kamishikiryo Toshiharu, Kircher Tilo, Koopowitz Sheri-Michelle, Krämer Bernd, Kraus Anna, Krieger Judith, Krug Axel, Lagopoulos Jim, Li Meng, McIntosh Andrew, Meinert Susanne, Melloni Elisa M T, Mwangi Benson, Nenadic Igor, Ojha Amar, Okada Go, Oudega Mardien L, Penninx Brenda W J H, Poletti Sara, Pomarol-Clotet Edith, Portella Maria J, Reneman Liesbeth, Rodriguez-Cano Elena, Sacchet Matthew, Salvador Raymond, Schrantee Anouk, Shinzato Hotaka, Sim Kang, Slump Theresa M, Soares Jair C, Stein Dan J, Stein Frederike, Teutenberg Lea, Thomas-Odenthal Florian, Thomopoulos Sophia I, van der Wee Nic J A, van der Werff Steven J A, Völzke Henry, Walter Martin, Whalley Heather C, Whittle Sarah, Wittfeld Katharina, Wu Mon-Ju, Yang Tony T, Zarate Carlos, Zunta-Soares Giovana B, Thompson Paul M, Veltman Dick J, Pozzi Elena, Schmaal Lianne, Schmidt André. Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.. Translational psychiatry. 2026. DOI: 10.1038/s41398-026-04189-x.

Предметные рубрики MeSH

HumansMajor Depressive DisorderFemaleMaleMiddle AgedAdultAdolescentMagnetic Resonance ImagingAgedChildYoung AdultAged, 80 and overCerebral CortexBrain Cortical ThicknessGyrus CinguliAntidepressive Agents
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