Insomnia disorder and cerebrospinal fluid markers of dementia.

Sleep disturbance may increase risk of Alzheimer's disease and related dementias (ADRD). Acute sleep deprivation increases cerebrospinal fluid (CSF) levels of amyloid-β, but the impact of chronic insomnia remains unclear. We compared 13 adults aged 30-60 with Insomnia Disorder to matched good sleepers. After overnight polysomnography a lumbar puncture was performed to collect CSF for assays of ADRD biomarkers. Contrary to our hypotheses, we found no significant differences in objective sleep measures or any CSF biomarkers, except for lower levels of neurofilament light. These findings suggest that mild-to-moderate Insomnia Disorder may not increase ADRD biomarkers, contrasting with effects of acute sleep deprivation.