Environment international · 2026
Fetal phthalate exposure and asthma outcomes from infancy to adolescence: Individual participant data meta-analysis in the EU Child Cohort Network.
СтатьяМетаанализНазвание и аннотация: Перевод в очереди
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Karramass Tarik, Duijts Liesbeth, Avraam Demetris, Blaauwendraad Sophia, Carrasco Paula, Güil-Oumrait Nuria, Irizar Amaia, Kadawathagedara Manik, Karachaliou Marianna, Lopez-Espinosa Maria-Jose, Myridakis Antonis, Rouxel Elke, Sakhi Amrit Kaur, Thomsen Cathrine, Vainqueur Chloe, Vrijheid Martine, Warembourg Charline, Welten Marieke, Zabaleta Carlos, Trasande Leonardo, Jaddoe Vincent
Аннотация
OBJECTIVE: Early-life exposure to phthalates, widely used in consumer products, may induce developmental lung adaptations and predispose to respiratory morbidity throughout childhood. We assessed the associations of fetal phthalate exposure with wheezing, asthma, and lung function from birth to adolescence.
METHODS: We performed 1-stage individual participant data meta-analyses with data from six European birth cohorts (3,745 mother-child pairs) to assess associations of pregnancy-averaged maternal urinary concentrations of 7 phthalate metabolites and 3 phthalate groups (high- and low-molecular-weight phthalate metabolites and sum of di-2-ethylhexyl phthalate metabolites) with wheezing in infancy (0-1 years) and at preschool age (1-5 years), and asthma and lung function at school age (5-12 years).
RESULTS: Higher maternal pregnancy urine phthalate concentrations were not associated with wheezing in infancy or preschool age. Higher maternal pregnancy urine mono-benzyl phthalate concentrations were associated with an increased risk of asthma at school age (odds ratio (95% confidence interval): 1.13 (1.01-1.26) per natural log interquartile range unit increase in concentration), but not with wheezing or lung function and attenuated into non-significance after multiple testing correction. Higher maternal pregnancy concentrations of mono-2-ethyl-5-hydroxyhexyl phthalate, mono-iso-butyl phthalate, mono-n-butyl phthalate and low-molecular-weight phthalate metabolites were associated with higher FEV1, FEV1/FVC and FEF75 z-scores after multiple testing correction.
CONCLUSION: Fetal exposure to higher phthalate concentrations is associated with lung function adaptations, while overall no consistent associations were observed with childhood wheezing or asthma. Future studies are needed to assess the causality of the observed associations, to identify the underlying mechanisms, and to assess potential respiratory consequences in adult life.
METHODS: We performed 1-stage individual participant data meta-analyses with data from six European birth cohorts (3,745 mother-child pairs) to assess associations of pregnancy-averaged maternal urinary concentrations of 7 phthalate metabolites and 3 phthalate groups (high- and low-molecular-weight phthalate metabolites and sum of di-2-ethylhexyl phthalate metabolites) with wheezing in infancy (0-1 years) and at preschool age (1-5 years), and asthma and lung function at school age (5-12 years).
RESULTS: Higher maternal pregnancy urine phthalate concentrations were not associated with wheezing in infancy or preschool age. Higher maternal pregnancy urine mono-benzyl phthalate concentrations were associated with an increased risk of asthma at school age (odds ratio (95% confidence interval): 1.13 (1.01-1.26) per natural log interquartile range unit increase in concentration), but not with wheezing or lung function and attenuated into non-significance after multiple testing correction. Higher maternal pregnancy concentrations of mono-2-ethyl-5-hydroxyhexyl phthalate, mono-iso-butyl phthalate, mono-n-butyl phthalate and low-molecular-weight phthalate metabolites were associated with higher FEV1, FEV1/FVC and FEF75 z-scores after multiple testing correction.
CONCLUSION: Fetal exposure to higher phthalate concentrations is associated with lung function adaptations, while overall no consistent associations were observed with childhood wheezing or asthma. Future studies are needed to assess the causality of the observed associations, to identify the underlying mechanisms, and to assess potential respiratory consequences in adult life.