Clinical and experimental dental research · 2026
Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation.
СтатьяНазвание и аннотация: Перевод в очереди
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Alves Ana Catarina Rios Castro, da Silva Adonias Antonio, da Silva Roberta Bruno, de Lima França Rayan, Romão Dayse Andrade, de Fragoso, Dos Santos Natanael Barbosa, de Porto
Аннотация
INTRODUCTION: Polyphenols have been investigated in dental materials and restorative techniques due to their interactions with metal cations, antioxidant activity, and collagen crosslinking ability, which make them a promise for reinforcing the dental substrate and improving material adhesion. However, more studies are necessary before to support their use in clinical procedures.
OBJECTIVES: This study evaluated the effects of quercetin and resveratrol on bond strength and the protection of dentin collagen fibrils against enzymatic degradation.
MATERIALS AND METHODS: Demineralized human dentin specimens were immersed for 1 min in solutions of quercetin or resveratrol (100, 250, and 500 µg/mL), 2% chlorhexidine (CHX), or 0.9% saline (control). The specimens were then incubated in collagenase for 24 h at 37°C, and changes in dry mass were measured. For microtensile bond strength testing, quercetin, resveratrol, CHX, or distilled water (DW) were applied to phosphoric acid-conditioned dentin, followed by application of Single Bond 2 (3 M/ESPE) adhesive and Z350XT resin (3 M/ESPE). Adhesive strength was measured after 24 h and after 1 year in distilled water. Data were analyzed using the Kruskal-Wallis and Dunn tests or ANOVA followed by Tukey's test (p < 0.05).
RESULTS: Quercetin-treated specimens showed a significant weight increase compared with CHX (p < 0.05). Both quercetin- and resveratrol-treated groups exhibited resistance to collagenase similar to CHX (p > 0.05). After 1 year, only the DW group showed a significant decrease in bond strength (p = 0.001).
CONCLUSIONS: Dentin treatment with quercetin or resveratrol effectively preserved adhesive strength and protected collagen against enzymatic degradation, suggesting their potential as agents to improve the longevity of adhesive restorations.
OBJECTIVES: This study evaluated the effects of quercetin and resveratrol on bond strength and the protection of dentin collagen fibrils against enzymatic degradation.
MATERIALS AND METHODS: Demineralized human dentin specimens were immersed for 1 min in solutions of quercetin or resveratrol (100, 250, and 500 µg/mL), 2% chlorhexidine (CHX), or 0.9% saline (control). The specimens were then incubated in collagenase for 24 h at 37°C, and changes in dry mass were measured. For microtensile bond strength testing, quercetin, resveratrol, CHX, or distilled water (DW) were applied to phosphoric acid-conditioned dentin, followed by application of Single Bond 2 (3 M/ESPE) adhesive and Z350XT resin (3 M/ESPE). Adhesive strength was measured after 24 h and after 1 year in distilled water. Data were analyzed using the Kruskal-Wallis and Dunn tests or ANOVA followed by Tukey's test (p < 0.05).
RESULTS: Quercetin-treated specimens showed a significant weight increase compared with CHX (p < 0.05). Both quercetin- and resveratrol-treated groups exhibited resistance to collagenase similar to CHX (p > 0.05). After 1 year, only the DW group showed a significant decrease in bond strength (p = 0.001).
CONCLUSIONS: Dentin treatment with quercetin or resveratrol effectively preserved adhesive strength and protected collagen against enzymatic degradation, suggesting their potential as agents to improve the longevity of adhesive restorations.