Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025
Effects of sodium nitroprusside on the default mode network of patients with schizophrenia and healthy controls.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Garcia Giovana Jorge, Rossi Giordano Novak, Dias Isabella Caroline da Silva, Arcoverde Emerson, Palhano-Fontes Fernanda, Onias Heloisa, de Sousa João Paulo Machado, de Oliveira João Paulo Maia, Araújo Draulio B, Lacerda Acioly L T, Dos Santos Rafael Guimarães, Baker Glen B, Dursun Serdar Murat, Hallak Jaime Eduardo Cecílio
Аннотация
OBJECTIVE: Brain default mode network (DMN) function is altered in schizophrenia (SZ). Considering the roles of nitrergic and glutamatergic transmission in SZ neurobiology, supplementation with nitric oxide (NO) donors such as sodium nitroprusside (SNP) has been proposed as a means of reducing symptoms, but results have been mixed and potential mechanisms remain unclear. In this context, we sought to investigate the effects of SNP on DMN functional connectivity (FC) assessed by functional magnetic resonance imaging (fMRI) in SZ patients and healthy controls.
METHODS: In an open-label trial, participants were divided into three treatment groups to receive intravenous SNP (0.25 µg/kg/min over 12 minutes): SZ patients on clozapine (CLZ) (n=13), SZ patients on non-CLZ antipsychotics (n=13), and controls (n=14). fMRI data was collected continuously before, during, and after SNP infusion. Symptom changes were evaluated with the Brief Psychiatric Rating Scale (BPRS).
RESULTS: Considering only patient groups at baseline, there was no difference in connectivity. When comparing all patient groups to controls, patients exhibited increased activity in DMN subregions and increased FC in the left supramarginal gyrus. During SNP infusion, FC was increased in the left angular gyrus; immediately following infusion, FC increased in the bilateral medial temporal gyri and left supramarginal gyrus of patients compared to controls. There were no significant differences between patient groups at any time point, nor changes in symptoms.
CONCLUSION: Although our results are preliminary, this work demonstrated for the first time that SNP modulates brain connectivity in healthy controls and patients with SZ. Future research is warranted to confirm these findings.
METHODS: In an open-label trial, participants were divided into three treatment groups to receive intravenous SNP (0.25 µg/kg/min over 12 minutes): SZ patients on clozapine (CLZ) (n=13), SZ patients on non-CLZ antipsychotics (n=13), and controls (n=14). fMRI data was collected continuously before, during, and after SNP infusion. Symptom changes were evaluated with the Brief Psychiatric Rating Scale (BPRS).
RESULTS: Considering only patient groups at baseline, there was no difference in connectivity. When comparing all patient groups to controls, patients exhibited increased activity in DMN subregions and increased FC in the left supramarginal gyrus. During SNP infusion, FC was increased in the left angular gyrus; immediately following infusion, FC increased in the bilateral medial temporal gyri and left supramarginal gyrus of patients compared to controls. There were no significant differences between patient groups at any time point, nor changes in symptoms.
CONCLUSION: Although our results are preliminary, this work demonstrated for the first time that SNP modulates brain connectivity in healthy controls and patients with SZ. Future research is warranted to confirm these findings.