Ambient Air Pollution Is Particularly Associated with Visceral Fat Accumulation in Men: A Large-Scale Korean Adult Study.

UNLABELLED: <p>

Introduction

Long-term air pollution exposure is associated with obesity, but its impact on visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) distribution remains unclear. This study investigated the association between air pollution and abdominal fat indicators, including total adipose tissue, VAT, SAT, and the visceral-to-subcutaneous fat ratio (VSR), stratified by sex and obesity status based on body mass index (BMI).

METHODS

A total of 8,912 Korean adults who underwent health checkups at Seoul National University Hospital were included. Abdominal fat was measured using CT scans. Annual average air pollution exposure levels, including particulate matter ≤2.5 μm in diameter, particulate matter ≤10 μm in diameter (PM10), NO2, SO2, CO, and O3, were estimated using the Community Multiscale Air Quality model. Ambient air pollution exposure and abdominal adiposity-related traits were analyzed using multiple linear and logistic regression, stratified by sex.

RESULTS

Annual exposure to PM10 and SO2 was positively associated with VAT (PM10: β = 2.29, 95% CI: 0.53-4.04, p = 0.01; SO2: β = 4.19, 95% CI: 2.43-5.94, p < 0.001) and VSR (PM10: β = 0.03, 95% CI: 0.01-0.05, p = 0.001; SO2: β = 0.05, 95% CI: 0.03-0.07, p < 0.001) in men. These associations were stronger in men with high BMI, but no significant associations were found in women. Negative associations with SAT were observed for PM10 (β = -1.94, 95% CI: -3.44 to -0.45, p = 0.01) and SO2 (β = -2.47, 95% CI: -3.97 to -0.98, p = 0.001) in men and for PM10 (β = -4.58, 95% CI: -7.23 to -1.93, p = 0.001) and SO2 (β = -8.13, 95% CI: -10.78 to -5.48, p < 0.001) in women.

CONCLUSION

Long-term exposure to air pollutants, including PM10 and SO2, may have detrimental effects by increasing visceral fat accumulation and reducing beneficial subcutaneous fat, especially in men with obesity. </p>.