Legal medicine (Tokyo, Japan) · 2010
Blood concentrations of clobazam and norclobazam in a lethal case involving clobazam, meprobamate and clorazepate.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Pok Phak-Rop Pos, Mauras Michel, De Saint Léger Marie-Noëlle, Kuhlmann Erika, Charpenel-Durat Catherine, Navarette Claudie, Duval Marie-Laure, De Meo Pierre
Аннотация
Clobazam is a benzodiazepine with anti-anxiety and anticonvulsant properties marketed in several countries. Norclobazam, a metabolite of clobazam, has similar pharmacological activity but weaker sedative and tranquilizing effect. The two drugs were detected by GC-MS and determined by HPLC-DAD in the samples from a postmortem case. The femoral blood concentrations of clobazam and norclobazam were 0.72 and 36 μg/mL, respectively. The concentration of the active norclobazam was very high. The sum of both clobazam and norclobazam blood concentration (36.72 μg/mL) was clearly toxic, but was not necessarily fatal. Other associated drugs concentrations were within their therapeutic ranges. Interactions due to drug association were discussed.