Transactions of the Royal Society of Tropical Medicine and Hygiene · 2021
Melanin production in coelomycetous agents of black grain eumycetoma.
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Lim Wilson, Parel Florianne, de Hoog Sybren, Verbon Annelies, van de Sande Wendy W J
Аннотация
BACKGROUND: Eumycetoma is a fungal infection characterised by the formation of black grains by causative agents. The melanin biosynthetic pathways used by the most common causative agents of black-grain mycetoma are unknown and unravelling them could identify potential new therapeutic targets.
METHOD: Melanin biosynthetic pathways in the causative fungi were identified by the use of specific melanin inhibitors.
RESULTS: In Trematosphaeria grisea and Falciformispora tompkinsii, 1,8-dihydroxynaphthalene (DHN)-melanin synthesis was inhibited, while DHN-, 3,4-dihydroxyphenylalanine (DOPA)- and pyo-melanin were inhibited in Medicopsis romeroi and Falciformispora senegalensis.
CONCLUSION: Our data suggest that Me. romeroi and F. senegalensis synthesise DHN-, DOPA- and pyo-melanin, while T. grisea and F. tompkinsii only synthesise DHN-melanin.
METHOD: Melanin biosynthetic pathways in the causative fungi were identified by the use of specific melanin inhibitors.
RESULTS: In Trematosphaeria grisea and Falciformispora tompkinsii, 1,8-dihydroxynaphthalene (DHN)-melanin synthesis was inhibited, while DHN-, 3,4-dihydroxyphenylalanine (DOPA)- and pyo-melanin were inhibited in Medicopsis romeroi and Falciformispora senegalensis.
CONCLUSION: Our data suggest that Me. romeroi and F. senegalensis synthesise DHN-, DOPA- and pyo-melanin, while T. grisea and F. tompkinsii only synthesise DHN-melanin.