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DOI 10.1080/09553002.2021.1941380

Медицинская библиотека · International journal of radiation biology · 2021

RENEB/EURADOS field exercise 2019: robust dose estimation under outdoor conditions based on the dicentric chromosome assay.

Endesfelder David, Oestreicher Ursula, Kulka Ulrike, Ainsbury Elizabeth A, Moquet Jayne, Barnard Stephen, Gregoire Eric, Martinez Juan S, Trompier François, Ristic Yoann, Woda Clemens, Waldner Lovisa, Beinke Christina, Vral Anne, Barquinero Joan-Francesc, Hernandez Alfredo, Sommer Sylwester, Lumniczky Katalin, Hargitai Rita, Montoro Alegría, Milic Mirta, Monteiro Gil Octávia, Valente Marco, Bobyk Laure, Sevriukova Olga, Sabatier Laure, Prieto María Jesús, Moreno Domene Mercedes, Testa Antonella, Patrono Clarice, Terzoudi Georgia, Triantopoulou Sotiria, Histova Rositsa, Wojcik Andrzej

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Аннотация

PURPOSE: Biological and/or physical assays for retrospective dosimetry are valuable tools to recover the exposure situation and to aid medical decision making. To further validate and improve such biological and physical assays, in 2019, EURADOS Working Group 10 and RENEB performed a field exercise in Lund, Sweden, to simulate various real-life exposure scenarios.

MATERIALS AND

METHODS

For the dicentric chromosome assay (DCA), blood tubes were located at anthropomorphic phantoms positioned in different geometries and were irradiated with a 1.36 TBq 192Ir-source. For each exposure condition, dose estimates were provided by at least one laboratory and for four conditions by 17 participating RENEB laboratories. Three radio-photoluminescence glass dosimeters were placed at each tube to assess reference doses.

RESULTS

The DCA results were homogeneous between participants and matched well with the reference doses (≥95% of estimates within ±0.5 Gy of the reference). For samples close to the source systematic underestimation could be corrected by accounting for exposure time. Heterogeneity within and between tubes was detected for reference doses as well as for DCA doses estimates.

CONCLUSIONS

The participants were able to successfully estimate the doses and to provide important information on the exposure scenarios under conditions closely resembling a real-life situation.

Для цитирования: Endesfelder David, Oestreicher Ursula, Kulka Ulrike, Ainsbury Elizabeth A, Moquet Jayne, Barnard Stephen, Gregoire Eric, Martinez Juan S, Trompier François, Ristic Yoann, Woda Clemens, Waldner Lovisa, Beinke Christina, Vral Anne, Barquinero Joan-Francesc, Hernandez Alfredo, Sommer Sylwester, Lumniczky Katalin, Hargitai Rita, Montoro Alegría, Milic Mirta, Monteiro Gil Octávia, Valente Marco, Bobyk Laure, Sevriukova Olga, Sabatier Laure, Prieto María Jesús, Moreno Domene Mercedes, Testa Antonella, Patrono Clarice, Terzoudi Georgia, Triantopoulou Sotiria, Histova Rositsa, Wojcik Andrzej. RENEB/EURADOS field exercise 2019: robust dose estimation under outdoor conditions based on the dicentric chromosome assay.. International journal of radiation biology. 2021. DOI: 10.1080/09553002.2021.1941380.

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