American journal of obstetrics and gynecology · 2010
Long-term outcome of children with congenital toxoplasmosis.
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Berrébi Alain, Assouline Corinne, Bessières Marie-Hélène, Lathière Myriam, Cassaing Sophie, Minville Vincent, Ayoubi Jean-Marc
Аннотация
OBJECTIVE: Maternal toxoplasmosis infection acquired during pregnancy carries significant risk of fetal damage. We aimed to assess the long-term outcome of children and young adults with congenital toxoplasmosis diagnosed and treated in utero.
STUDY DESIGN: This was a 20 year prospective study (1985-2005). All mothers received spiramycin, alone or associated with pyrimethamine-sulfadoxine, and underwent amniocentesis and monthly ultrasound screening. Infected children were followed every 3-6 months.
RESULTS: Of 666 liveborn children (676 mothers), 112 (17%) had congenital toxoplasmosis. Among these, 107 were followed up for 12-250 months: 79 were asymptomatic (74%) and 28 had chorioretinitis (26%). Only 1 child had a serious neurological involvement.
CONCLUSION: The percentage of chorioretinitis in treated children depends on length of follow-up, but this complication occurs mainly before the age of 5 years and almost always before the age of 10 years. Visual impairment was infrequently severe, and outcome appears consistently good. Long-term follow-up is recommended to monitor ocular and neurological prognosis, whatever the practical difficulties.
STUDY DESIGN: This was a 20 year prospective study (1985-2005). All mothers received spiramycin, alone or associated with pyrimethamine-sulfadoxine, and underwent amniocentesis and monthly ultrasound screening. Infected children were followed every 3-6 months.
RESULTS: Of 666 liveborn children (676 mothers), 112 (17%) had congenital toxoplasmosis. Among these, 107 were followed up for 12-250 months: 79 were asymptomatic (74%) and 28 had chorioretinitis (26%). Only 1 child had a serious neurological involvement.
CONCLUSION: The percentage of chorioretinitis in treated children depends on length of follow-up, but this complication occurs mainly before the age of 5 years and almost always before the age of 10 years. Visual impairment was infrequently severe, and outcome appears consistently good. Long-term follow-up is recommended to monitor ocular and neurological prognosis, whatever the practical difficulties.
Предметные рубрики MeSH
Age FactorsChildChild DevelopmentChild, PreschoolChorioretinitisCohort StudiesDrug CombinationsFemaleFollow-Up StudiesHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMaleMonitoring, PhysiologicPregnancyPregnancy Complications, InfectiousProspective StudiesPyrimethamineRisk AssessmentSpiramycinSulfadoxineTime FactorsToxoplasmosis, CongenitalToxoplasmosis, Ocular