Clinical effectiveness of quetiapine in children and adolescents with Tourette's syndrome : a retrospective case-note survey.
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Aydi Elias, Monnier John D, Mérand Antoine, Schaefer Gail H, Chomiuk Laura, Otulakowska-Hypka Magdalena, Fan Jhih-Ling, Li Kwan Lok, Sokolovsky Kirill V, Salinas Ricardo, Tucker Michael, Shappee Benjamin, Rudy Richard, Page Kim L, Kuin N Paul M, Buckley David A H, Craig Peter, Izzo Luca, Linford Justin, Metzger Brian D, Mukai Koji, Orio Marina, Shen Ken J, Strader Jay, Sokoloski Jennifer L, Williams Robert E, Williams Montana N, Habtie Gesesew R, Kraus Stefan, Anugu Narsireddy, Bouquin Jean-Baptiste Le, Chhabra Sorabh, Codron Isabelle, Gardner Tyler, Gutierrez Mayra, Ibrahim Noura, Lanthermann Cyprien, Setterholm Benjamin R, Ashall Christopher, Hinkle Jason T, Jaeger Thomas de, Payne Anna V
Аннотация
PATIENTS AND METHODS: The study comprised 45 women with genuine stress urinary incontinence. To assess the voiding phase, patients were asked if their voiding had changed after surgery, and objectively the uroflowmetry, residual urine measurements and pressure-flow data were compared.
RESULTS: At 1 year after surgery 39 women (87%) were subjectively cured and six (13%) improved. The objective cure rate was 88%; the pad-test leakage and the number of leakage episodes decreased significantly after surgery. Subjectively, 78% of the patients reported that the voiding phase had become more difficult, and the spontaneous flow curve changed to a more obstructive pattern in 40%, with the mean urinary peak flow rate (Q(max)), the corrected Q(max) and the mean average flow rate decreasing significantly. The residual urine volume increased significantly, although no patient had volumes of > 25% of their bladder capacity. During the pressure-flow study the Q(max) decreased and the urethral resistance factor increased significantly. However, only one patient could be classified as obstructed. Two patients had clinical problems and used self-catheterization once daily 1 year after surgery.
CONCLUSION: There were subjective and objective changes in the voiding phase 1 year after the TVT procedure. The significance of these findings remains to be determined. Longitudinal studies are warranted to clarify whether the patients at risk can be characterized from subjective and objective findings.