Neonatal undernutrition and short term administration of hydrocortisone and thyroxine: effects on rat brain hydrolases.

Brain enzymes activities that are likely to be involved in the catabolism of gangliosides were determined in controls (20% casein diet), postnatally undernourished (6.5% casein diet) and undernourished rats treated with either thyroxine or hydrocortisone, at 21 days of age. Postnatal undernutrition imposed by maternal protein deficiency during lactation resulted in a decrease in body weight and brain wet weight of the pups at 21 days of age. Administration of thyroxine or hydrocortisone to the undernourished pups every day between 16 and 21 days caused a further decrease in the body weight of the pups. On the other hand, the wet weight of brain showed a slight gain following hydrocortisone treatment. Postnatal undernutrition during lactation elevated the activities of beta-glucosidase, beta-galactosidase, beta-hexosaminidase and sialidase in rat brain. Short-term administration of thyroxine or hydrocortisone to the undernourished pups, every day between 16 and 21 days postnatal age decreased the enzyme activities. However, reversal of the increased enzyme activities to the normal lower level was completed only in the case of undernourished pups treated with hydrocortisone.