Conception and spontaneous delivery after total hypophysectomy.

OBJECTIVE

To report the first case of pregnancy and spontaneous delivery after total hypophysectomy.

DESIGN

A case report.

SETTING

University hospital.

PATIENT(S): A 34-year-old woman with panhypopituitarism after hypophysectomy in childhood for craniopharyngioma.

INTERVENTION(S): Successful fertility treatment followed by sufficient hormone substitution therapy during pregnancy.

MAIN OUTCOME MEASURE(S): Clinical variables.

RESULT(S): The patient had an uncomplicated spontaneous delivery without any substitution of oxytocin before, during, or after delivery.

CONCLUSION(S): Normal pregnancy and delivery are possible in women with lack of pituitary function. Maternal pituitary oxytocin release seems to play a limited role in the onset and progression of labor.