Fertility and sterility · 2008
Pregnancy in a hermaphrodite with a male-predominant mosaic karyotype.
Клинический случайСтатьяОбзорНазвание и аннотация: Перевод в очереди
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Schoenhaus Samantha A, Lentz Scott E, Saber Peter, Munro Malcom G, Kivnick Seth
Аннотация
OBJECTIVE: To report a pregnancy in a hermaphrodite and review of the literature.
DESIGN: Case report and literature review.
SETTING: Clinical.
PATIENT(S): A patient with male-predominant mosaic karyotype 96% 46XY.
INTERVENTION(S): Removal of left ovotestis in combination with a supracervical hysterectomy and bilateral salpingo-oophorectomy.
MAIN OUTCOME MEASURE(S): Identification of published cases of pregnancy and hermaphroditism.
RESULT(S): The current patient had previous pregnancy and a wedge biopsy of her left gonad, which demonstrated an ovotestis and an area suspicious for a gonadoblastoma. After delivery of her second pregnancy, the patient underwent a hysterectomy and bilateral salpingo-oophorectomy. The histopathologic evaluation following bilateral oophorectomy demonstrated a residual ovotestis without further evidence of a gonadoblastoma. Review of the literature identified 10 other cases of pregnancy in a hermaphrodite patient.
CONCLUSION(S): This is the 11th reported case of fertility in a true hermaphrodite and only the second report of a mosaic true hermaphrodite to demonstrate fertility. This is the only case of a pregnancy involving a male-predominant mosaic 96% 46XY and the only case to confirm the genetics of the offspring.
DESIGN: Case report and literature review.
SETTING: Clinical.
PATIENT(S): A patient with male-predominant mosaic karyotype 96% 46XY.
INTERVENTION(S): Removal of left ovotestis in combination with a supracervical hysterectomy and bilateral salpingo-oophorectomy.
MAIN OUTCOME MEASURE(S): Identification of published cases of pregnancy and hermaphroditism.
RESULT(S): The current patient had previous pregnancy and a wedge biopsy of her left gonad, which demonstrated an ovotestis and an area suspicious for a gonadoblastoma. After delivery of her second pregnancy, the patient underwent a hysterectomy and bilateral salpingo-oophorectomy. The histopathologic evaluation following bilateral oophorectomy demonstrated a residual ovotestis without further evidence of a gonadoblastoma. Review of the literature identified 10 other cases of pregnancy in a hermaphrodite patient.
CONCLUSION(S): This is the 11th reported case of fertility in a true hermaphrodite and only the second report of a mosaic true hermaphrodite to demonstrate fertility. This is the only case of a pregnancy involving a male-predominant mosaic 96% 46XY and the only case to confirm the genetics of the offspring.