Science translational medicine · 2018
Acute and chronic neurological consequences of early-life Zika virus infection in mice.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Nem de Oliveira Souza Isis, Frost Paula S, França Julia V, Nascimento-Viana Jéssica B, Neris Rômulo L S, Freitas Leandro, Pinheiro Daniel J L L, Nogueira Clara O, Neves Gilda, Chimelli Leila, De Felice Fernanda G, Cavalheiro Ésper A, Ferreira Sergio T, Assunção-Miranda Iranaia, Figueiredo Claudia P, Da Poian Andrea T, Clarke Julia R
Аннотация
Although congenital Zika virus (ZIKV) exposure has been associated with microcephaly and other neurodevelopmental disorders, long-term consequences of perinatal infection are largely unknown. We evaluated short- and long-term neuropathological and behavioral consequences of neonatal ZIKV infection in mice. ZIKV showed brain tropism, causing postnatal-onset microcephaly and several behavioral deficits in adulthood. During the acute phase of infection, mice developed frequent seizures, which were reduced by tumor necrosis factor-α (TNF-α) inhibition. During adulthood, ZIKV replication persisted in neonatally infected mice, and the animals showed increased susceptibility to chemically induced seizures, neurodegeneration, and brain calcifications. Altogether, the results show that neonatal ZIKV infection has long-term neuropathological and behavioral complications in mice and suggest that early inhibition of TNF-α-mediated neuroinflammation might be an effective therapeutic strategy to prevent the development of chronic neurological abnormalities.