Annals of medicine · 2025
Risk factors for bronchiolitis obliterans in children with community-acquired pneumonia and analysis of CT findings and clinical manifestations of pneumonia after the diagnosis of bronchiolitis obliterans.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Hou Jiapu, Sun Ruiyang, Zhang Xue, Jia Wanyu, Li Peng, Jin Zhipeng, Song Chunlan
Аннотация
OBJECTIVE: We explore the risk factors associated with the development of Bronchiolitis obliterans in children with community-acquired pneumonia to provide some basis for the early diagnosis of Bronchiolitis obliterans.
METHODS: We retrospectively analysed 83 children with community-acquired pneumonia who developed Bronchiolitis obliterans from January 2023 to October 2024 as the observation group, and 83 children with community-acquired pneumonia who did not develop Bronchiolitis obliterans for more than 1 year of follow-up as the control group. We performed a one-way logistic regression analysis of the clinical data of the two groups and further performed a multifactorial logistic regression analysis to determine the independent risk factors for the development of bronchiolitis obliterans in children with pneumonia. We analysed the ROC curves to determine the cut-off value of the indicator with the greatest diagnostic value.
RESULTS: The results of univariate and multivariate logistic regression analyses revealed that the independent risk factors for the development of bronchiolitis obliterans in children with pneumonia were age in months (OR = 0.982, p = 0.011), days of hospitalization (OR = 1.132, p = 0.043), dyspnoea (OR = 21.374, p < 0.001), pulmonary consolidation (OR = 5.267, p = 0.016) and endobronchitis (OR = 6.421, p = 0.002). The areas under the ROC curves were 0.700, 0.707, 0.711, 0.702 and 0.764 (p < 0.001), respectively. The critical values for months and days of hospitalization were 83 months and 10 days. In this study, 24 children in the observation group had bronchiectasis, 22 had bronchial stenosis, and 8 had pulmonary necrosis after the diagnosis of bronchiolitis obliterans.
CONCLUSIONS: In children with community-acquired pneumonia who are less than 83 months of age, have been hospitalised for more than 10 days, and have dyspnoea, pulmonary consolidation, and endobronchitis, we should be vigilant for bronchiolitis obliterans to achieve early intervention and treatment.
METHODS: We retrospectively analysed 83 children with community-acquired pneumonia who developed Bronchiolitis obliterans from January 2023 to October 2024 as the observation group, and 83 children with community-acquired pneumonia who did not develop Bronchiolitis obliterans for more than 1 year of follow-up as the control group. We performed a one-way logistic regression analysis of the clinical data of the two groups and further performed a multifactorial logistic regression analysis to determine the independent risk factors for the development of bronchiolitis obliterans in children with pneumonia. We analysed the ROC curves to determine the cut-off value of the indicator with the greatest diagnostic value.
RESULTS: The results of univariate and multivariate logistic regression analyses revealed that the independent risk factors for the development of bronchiolitis obliterans in children with pneumonia were age in months (OR = 0.982, p = 0.011), days of hospitalization (OR = 1.132, p = 0.043), dyspnoea (OR = 21.374, p < 0.001), pulmonary consolidation (OR = 5.267, p = 0.016) and endobronchitis (OR = 6.421, p = 0.002). The areas under the ROC curves were 0.700, 0.707, 0.711, 0.702 and 0.764 (p < 0.001), respectively. The critical values for months and days of hospitalization were 83 months and 10 days. In this study, 24 children in the observation group had bronchiectasis, 22 had bronchial stenosis, and 8 had pulmonary necrosis after the diagnosis of bronchiolitis obliterans.
CONCLUSIONS: In children with community-acquired pneumonia who are less than 83 months of age, have been hospitalised for more than 10 days, and have dyspnoea, pulmonary consolidation, and endobronchitis, we should be vigilant for bronchiolitis obliterans to achieve early intervention and treatment.