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Войти в исследования Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Kennedy James T, Wisch Julie K, Boerwinkle Anna H, Millar Peter R, McKay Nicole S, Brickman Adam M, Chhatwal Jasmeer P, Mendez Patricio Chrem, Christian Bradley T, Cohen Anne, Cruchaga Carlos, Daniels Alisha, Flores Shaney, Handen Benjamin L, Hartley Sigan L, Head Elizabeth, Ibanez Laura, Krisnsky-McHale Sharon J, la Fougere Christian, Lai Florence, Laymon Charles M, Lee Joseph H, Lee Jae-Hong, Levin Johannes, Llibre-Guerra Jorge, Aguillon David F, Lott Ira T, Mapstone Mark, McDade Eric, Morris John, O'Bryant Sid E, Price Julie C, Rafii Michael S, Roh Jee Hoon, Rosas H Diana, Schupf Nicole, Supnet-Bell Charlene, Xiong Chengjie, Zaman Shahid, Benzinger Tammie L S, Gordon Brian A, Ances Beau M, Alzheimer's Brain Consortium – Down Syndrome, and the Dominantly Inherited Alzheimer's Network
Аннотация
METHODS: We compared brain volumes in DS, ADAD, and unaffected family members serving as controls. Participants underwent magnetic resonance imaging (MRI) and amyloid positron emission tomography (PET), deriving volumetric and amyloid burden, respectively. Nonlinear associations between regional volumes and estimated years to clinical symptom onset (EYO) were evaluated using generalized additive mixed-models.
RESULTS: Longitudinal data from 267 controls, 341 participants with DS, and 358 participants with ADAD were included, totaling 1908 scans. DS volumes were lower than ADAD and controls initially and dropped linearly. ADAD had similar volumes to controls until diverging, beginning at EYO -7. Amyloid was negatively associated with volume, with similar slopes in DS and ADAD.
DISCUSSION: ADAD and DS demonstrate distinct patterns of brain volume decline prior to symptom onset despite being similarly affected by amyloid.