International urology and nephrology · 2025
Outcome of children with fusion anomalies of the kidney: a single center experience from North India.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Taneja Sanjana, Dhull Rachita Singh, Saha Abhijeet, Agarwal Prajal, Kapoor Kanika
Аннотация
BACKGROUND: Crossed fused ectopia (CFE) and horseshoe kidney (HSK) are the fusion anomalies of the kidney. Due to paucity of data on these disorders from India, we assessed the clinico-radiological profile and outcomes of these children.
MATERIALS AND METHODS: Clinical records of radiologically confirmed cases of CFE and HSK, attending the Pediatric nephrology clinic at a tertiary care center were reviewed retrospectively.
RESULTS: Thirty one cases of fusion disorders of the kidney were studied (16 CFE, 15 HSK). The median age at diagnosis was 84 (37-123.5) months. Non-specific abdominal pain was the most common presenting complaint (42%). There was a significant difference between mean estimated GFR (97.23 ± 31.76 ml/min/1.73m2) and mean diethylenetriamine pentaacetate (DTPA) GFR (78.18 ± 21.21 ml/min) at presentation (p < 0.05). Hydronephrosis was seen in 13 (42%) children (3 obstructive, 10 non-obstructive). Seven patients (22.5%) showed scarring on dimercapto succinic acid (DMSA) scan. Four patients (12.9%) had urological and five patients (16%) had associated non-urological anomalies. Only 2 (6.5%) patients had hypertension (stage 1) at presentation. Though five patients (n = 14) showed declining renal function at the latest follow-up, there was no significant difference in the mean eGFR of the entire cohort at the one-year and the latest follow-up mark.
CONCLUSIONS: Most children with fusion anomalies of kidney are symptomatic at presentation and further treatment is guided by the presence of associated urological anomalies. These children have an overall good prognosis but close monitoring of renal functions is essential.
MATERIALS AND METHODS: Clinical records of radiologically confirmed cases of CFE and HSK, attending the Pediatric nephrology clinic at a tertiary care center were reviewed retrospectively.
RESULTS: Thirty one cases of fusion disorders of the kidney were studied (16 CFE, 15 HSK). The median age at diagnosis was 84 (37-123.5) months. Non-specific abdominal pain was the most common presenting complaint (42%). There was a significant difference between mean estimated GFR (97.23 ± 31.76 ml/min/1.73m2) and mean diethylenetriamine pentaacetate (DTPA) GFR (78.18 ± 21.21 ml/min) at presentation (p < 0.05). Hydronephrosis was seen in 13 (42%) children (3 obstructive, 10 non-obstructive). Seven patients (22.5%) showed scarring on dimercapto succinic acid (DMSA) scan. Four patients (12.9%) had urological and five patients (16%) had associated non-urological anomalies. Only 2 (6.5%) patients had hypertension (stage 1) at presentation. Though five patients (n = 14) showed declining renal function at the latest follow-up, there was no significant difference in the mean eGFR of the entire cohort at the one-year and the latest follow-up mark.
CONCLUSIONS: Most children with fusion anomalies of kidney are symptomatic at presentation and further treatment is guided by the presence of associated urological anomalies. These children have an overall good prognosis but close monitoring of renal functions is essential.