Modulation of Sirtuins to address aging related disorders through the use of selected phytochemicals.

BACKGROUND

Aging is a complex phenomenon involving oxidative stress, inflammation, and cellular damage subsequently leading to various disorders, such as cardiovascular diseases, neurodegenerative disorders, diabetes, and cancer. Sirtuin (SIRT) proteins are one of the major molecular factors that affect human aging. Sirtuins are a class of NAD+-dependent enzymes that control oxidative stress response, DNA damage repair, inflammation and metabolism, all of which are involved in aging and age-related diseases.

PURPOSE: The objective of this review is to elucidate the potential role of SIRT in the aging process and modulation of SIRT pathway through selected phytochemicals like Curcumin, Resveratrol, Quercetin, and Kaempferol.

RESULTS

Studies convincedly revealed that SIRT pathway represents a promising avenue for extending the human health span and addressing age-related conditions. Phytochemicals like Curcumin, Resveratrol, Quercetin, and Kaempferol have shown excellent potential to mediate aging effects through their potent antioxidant, anti-inflammatory, and regulatory activities. These potent bioactive compounds enhance oxidative stress response, genomic integrity, neuroprotective and anti-inflammatory activities through SIRT pathway modulation. Furthermore, in addition to antiaging effects, other therapeutic benefits are also associated with each compound including nervous disorders, cancer, and metabolic disorders are also briefly highlighted. Studies reported convincing evidence that Curcumin, Resveratrol, Quercetin, and Kaempferol, effectively modulate SIRT expression/activity leading to improved cell stress tolerance, reduced oxidation and enhanced metabolic state.

CONCLUSIONS

Collectively, studies revealed the comprehensive nutraceutical significance of Curcumin, Resveratrol, Quercetin, and Kaempferol as anti-aging therapeutics and warrant future studies to exploit the full potential of these natural compounds.