Медицинская библиотека · Respiratory investigation · 2025

Macrolide-resistant Mycoplasma pneumoniae infection prevalence increases again in Osaka.

Miyashita Naoyuki, Ogata Makoto, Fukuda Naoki, Yamura Akihisa, Ito Tomoki

СтатьяПеревод в очереди

Аннотация

OBJECTIVES

We investigated the prevalence rate and resistance mechanism of macrolide-resistant Mycoplasma pneumoniae strains between 2018 and 2024.

METHODS

We analyzed 367 patients with M. pneumoniae infection by the polymerase chain reaction method.

RESULTS

Macrolide-resistant M. pneumoniae was identified in nine of 51 patients (17.6 %) in 2018, 13 of 63 patients (20.6 %) in 2019, eight of 30 patients (26.7 %) in 2020, one of three patients in 2021, one of three patients in 2022, three of six patients in 2023, and 127 of 211 patients (60.2 %) in 2024. Prevalence of macrolide-resistant M. pneumoniae was significantly increased in 2024 compared to the years 2018-2020 (p < 0.0001). The majority of resistant strains had an A-to-G transition at position 2063 in the M. pneumoniae 23S rRNA domain V gene region, which is associated with high-level resistance to macrolides.

CONCLUSIONS

Our study demonstrated that the prevalence of macrolide-resistant M. pneumoniae is once again increasing in Osaka Prefecture.

Для цитирования: Miyashita Naoyuki, Ogata Makoto, Fukuda Naoki, Yamura Akihisa, Ito Tomoki. Macrolide-resistant Mycoplasma pneumoniae infection prevalence increases again in Osaka.. Respiratory investigation. 2025. DOI: 10.1016/j.resinv.2025.04.009.

Предметные рубрики MeSH

Humans Mycoplasma pneumoniae Macrolides Prevalence Pneumonia, Mycoplasma Drug Resistance, Bacterial Japan Male Female RNA, Ribosomal, 23S Adult Middle Aged Child Anti-Bacterial Agents Adolescent Child, Preschool Young Adult Aged

Подготовка и перевод публикации

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.