Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
The Oral Microbiome: A Silent Contributor to Systemic Health and Disease National Institutes of Health 2024 Workshop.
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Riscuta Gabriela, Wali Anil, Mongodin Emmanuel F, Verma Mukesh, Cardone Marco, Kim Hye-Sook, McNealy Tamara, Mohammed Altaf
Аннотация
Previously considered primarily only in the context of dental diseases, the oral microbiome is now recognized as a contributor to a variety of systemic diseases, including cancer and cardiovascular diseases. This commentary explores the evolving view of the oral cavity as a gateway to the body's broader physiologic networks, implicating oral microbiome dysbiosis in a spectrum of chronic conditions. Drawing on current evidence, we propose a re-envisioned healthcare model that integrates oral and systemic health and outline research gaps and clinical priorities to harness the oral microbiome for preventive and therapeutic gains, emphasizing cancer-relevant biomarkers and intervention opportunities.