Journal of the American Academy of Dermatology · 1995
Prepubertal acne: a cutaneous marker of androgen excess?
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De Raeve L, De Schepper J, Smitz J
Аннотация
BACKGROUND: Early-onset acne before obvious signs of puberty is an uncommon phenomenon.
OBJECTIVE: The aim of this study was to determine if prepubertal acne is associated with an excess of androgens.
METHODS: Basal and adrenocorticotrophic hormone-stimulated plasma androgen levels were measured and bone age was determined in 15 children with early-onset acne.
RESULTS: A late-onset adrenogenital syndrome caused by 21-hydroxylase deficiency was diagnosed in two children. These children had early pubic hair development and advanced bone maturation. Heterozygosity for 21-hydroxylase deficiency was found in three other children.
CONCLUSION: We recommend hormonal evaluation in children with prepubertal acne, especially those with associated advanced bone maturation and early pubarche.
OBJECTIVE: The aim of this study was to determine if prepubertal acne is associated with an excess of androgens.
METHODS: Basal and adrenocorticotrophic hormone-stimulated plasma androgen levels were measured and bone age was determined in 15 children with early-onset acne.
RESULTS: A late-onset adrenogenital syndrome caused by 21-hydroxylase deficiency was diagnosed in two children. These children had early pubic hair development and advanced bone maturation. Heterozygosity for 21-hydroxylase deficiency was found in three other children.
CONCLUSION: We recommend hormonal evaluation in children with prepubertal acne, especially those with associated advanced bone maturation and early pubarche.
Предметные рубрики MeSH
17-alpha-HydroxyprogesteroneAcne VulgarisAdrenal Hyperplasia, CongenitalAdrenocorticotropic HormoneAge Determination by SkeletonAge of OnsetAndrogensAndrostenedioneBasal MetabolismBiomarkersChildChild, PreschoolDehydroepiandrosteroneDehydroepiandrosterone SulfateFemaleHeterozygoteHumansHydroxyprogesteronesMalePubertySexual MaturationSteroid 21-HydroxylaseTestosterone