Experimental neurology · 2003
Cervical root repair in adult rats after transection: recovery of forelimb motor function.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Huang Ming-Chao, Chen Kuo-Chi, Chuang Tien-Yow, Chang Wen-Chi, Lee Liang-Shong, Huang Wen-Chung, Cheng Henrich
Аннотация
Functional recovery was achieved in rats after repairing the transected left sixth and seventh cervical roots. Intercostal nerves were used for reanastomosis between the transected roots and the spinal cord, and acidic fibroblast growth factor with fibrin glue was applied. Experimental rats showed relevant functional recovery of gait and grooming reflexes. Electromyography demonstrated less denervation and more regeneration. Horseradish peroxidase retrograde axonal tracing disclosed a statistically significant increase of motor neuron survival, suggesting that motor neuron survival was significantly correlated with functional recovery. It is our belief that this novel treatment strategy may help patients with similar injuries in the future.
Предметные рубрики MeSH
AnimalsAxonsBrachial Plexus NeuropathiesCell SurvivalDisease Models, AnimalDrug Administration RoutesDrug CombinationsElectromyographyFemaleFibrin Tissue AdhesiveFibroblast Growth Factor 1GroomingHorseradish PeroxidaseIntercostal NervesMotor ActivityMotor NeuronsNeckNerve RegenerationNeurosurgical ProceduresRadiculopathyRatsRats, Sprague-DawleyRecovery of FunctionTreatment Outcome