Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi · 2010
[Chronic hepatitis C in children: are extrahepatic manifestations an argument for standard therapy?].
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Azoicăi Alice Nicoleta, Moraru Evelina
Аннотация
UNLABELLED: Chronic hepatitis C is still an important health problem in children. Adequate management of those patients should be focused on two directions: disappearance or reduction of the viral load (conventional antiviral therapy) and treatment of autoimmune manifestations (corticoids, plasmapheresis, cytotoxic agents).
AIM: To associate extrahepatic manifestations with other disorders and to evaluate the evolution under specific (antiviral) and non-specific therapy.
MATERIALS AND METHODS: 43 children diagnosed with chronic hepatitis C and followed in the 2nd Pediatric Clinic Iaşi between January 2005 and June 2010.
RESULTS AND DISCUSSIONS: most children were diagnosed accidentally or for etiological investigations for elevated liver enzymes. Extrahepatic manifestations were found in 41.86% of patients, most of them with articular, skin and hematologic disorders, but also depression (2 cases) in those receiving interferon.
CONCLUSIONS: In children, extrahepatic manifestations in chronic hepatitis C infection are more rare than in adults, especially with articular involvement. In certain cases, interferon therapy can trigger those manifestations with an immune mechanism. It is essential to evaluate the autoimmunity markers before proceeding with antiviral therapy.
AIM: To associate extrahepatic manifestations with other disorders and to evaluate the evolution under specific (antiviral) and non-specific therapy.
MATERIALS AND METHODS: 43 children diagnosed with chronic hepatitis C and followed in the 2nd Pediatric Clinic Iaşi between January 2005 and June 2010.
RESULTS AND DISCUSSIONS: most children were diagnosed accidentally or for etiological investigations for elevated liver enzymes. Extrahepatic manifestations were found in 41.86% of patients, most of them with articular, skin and hematologic disorders, but also depression (2 cases) in those receiving interferon.
CONCLUSIONS: In children, extrahepatic manifestations in chronic hepatitis C infection are more rare than in adults, especially with articular involvement. In certain cases, interferon therapy can trigger those manifestations with an immune mechanism. It is essential to evaluate the autoimmunity markers before proceeding with antiviral therapy.