The Medical journal of Australia · 2007
The epidemiology of invasive group A streptococcal disease in Victoria, Australia.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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O'Grady Kerry-Ann F, Kelpie Loraine, Andrews Ross M, Curtis Nigel, Nolan Terence M, Selvaraj Gowri, Passmore Jonathan W, Oppedisano Frances, Carnie John A, Carapetis Jonathan R
Аннотация
OBJECTIVE: To estimate the incidence and severity of invasive group A streptococcal infection in Victoria, Australia.
DESIGN: Prospective active surveillance study.
SETTING: Public and private laboratories, hospitals and general practitioners throughout Victoria.
PATIENTS: People in Victoria diagnosed with group A streptococcal disease notified to the surveillance system between 1 March 2002 and 31 August 2004.
MAIN OUTCOME MEASURE: Confirmed invasive group A streptococcal disease.
RESULTS: We identified 333 confirmed cases: an average annual incidence rate of 2.7 (95% CI, 2.3-3.2) per 100,000 population per year. Rates were highest in people aged 65 years and older and those younger than 5 years. The case-fatality rate was 7.8%. Streptococcal toxic shock syndrome occurred in 48 patients (14.4%), with a case-fatality rate of 23%. Thirty cases of necrotising fasciitis were reported; five (17%) of these patients died. Type 1 (23%) was the most frequently identified emm sequence type in all age groups. All tested isolates were susceptible to penicillin and clindamycin. Two isolates (4%) were resistant to erythromycin.
CONCLUSION: The incidence of invasive group A streptococcal disease in temperate Australia is greater than previously appreciated and warrants greater public health attention, including its designation as a notifiable disease.
DESIGN: Prospective active surveillance study.
SETTING: Public and private laboratories, hospitals and general practitioners throughout Victoria.
PATIENTS: People in Victoria diagnosed with group A streptococcal disease notified to the surveillance system between 1 March 2002 and 31 August 2004.
MAIN OUTCOME MEASURE: Confirmed invasive group A streptococcal disease.
RESULTS: We identified 333 confirmed cases: an average annual incidence rate of 2.7 (95% CI, 2.3-3.2) per 100,000 population per year. Rates were highest in people aged 65 years and older and those younger than 5 years. The case-fatality rate was 7.8%. Streptococcal toxic shock syndrome occurred in 48 patients (14.4%), with a case-fatality rate of 23%. Thirty cases of necrotising fasciitis were reported; five (17%) of these patients died. Type 1 (23%) was the most frequently identified emm sequence type in all age groups. All tested isolates were susceptible to penicillin and clindamycin. Two isolates (4%) were resistant to erythromycin.
CONCLUSION: The incidence of invasive group A streptococcal disease in temperate Australia is greater than previously appreciated and warrants greater public health attention, including its designation as a notifiable disease.
Предметные рубрики MeSH
AdolescentAdultAge DistributionAge FactorsAgedAged, 80 and overChildChild, PreschoolFamily PracticeFasciitis, NecrotizingFemaleHumansIncidenceInfantInfant, NewbornLaboratories, HospitalMaleMiddle AgedProspective StudiesRisk FactorsSeverity of Illness IndexStreptococcal InfectionsStreptococcus pyogenesVictoria