The European respiratory journal · 2025
How do people with COPD walk? A European study on digitally measured real-world gait.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Delgado-Ortiz Laura, Buekers Joren, Chynkiamis Nikolaos, Demeyer Heleen, Frei Anja, Gimeno-Santos Elena, Hansen Clint, Hausdorff Jeffrey M, Hopkinson Nicholas S, Jansen Carl-Philipp, Kirsten Anne, Koch Sarah, Maetzler Walter, Megaritis Dimitrios, Puhan Milo A, Singleton David, Vogiatzis Ioannis, Watz Henrik, Del Din Silvia, Caulfield Brian, Becker Clemens, Rochester Lynn, Troosters Thierry, Garcia-Aymerich Judith
Аннотация
BACKGROUND: The amount of walking that people with COPD do is reduced. However, data on their manner of walking (i.e. gait) are still lacking. We characterised real-world gait in COPD by assessing levels and distributions of gait parameters, and comparing them across COPD severity and with healthy peers.
METHODS: 549 people with COPD from seven European sites and 19 healthy older adults wore single wearable devices (either Axivity AX6 or DynaPort MoveMonitor MM+) continuously for 1 week, from which we identified walking bouts, calculated 15 digital mobility outcomes (DMOs) aggregated at the weekly level, and compared them across COPD severity levels and with healthy peers.
RESULTS: Of the participants with COPD, 37% were female with a mean±sd age of 68±8 years and a post-bronchodilator forced expiratory volume in 1 s of 54±20% predicted. All gait DMOs were normally distributed and exhibited variability between participants (e.g. mean±sd walking speed of 0.83±0.12 m·s-1, ranging from 0.48 to 1.20 m·s-1). Walking speed and cadence DMOs were lower with increasing disease severity (e.g. mean±sd walking speed of 0.88±0.11, 0.85±0.12, 0.80±0.12 and 0.78±0.14 m·s-1 across Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 1 to 4, p<0.001; mean±sd cadence of 93±6, 91±6 and 89±7 steps·min-1 across GOLD A, B and E, p=0.013). Stride length and duration varied across COPD severity levels. Walking speed and cadence bout-to-bout variability only varied across dyspnoea severity levels. In a secondary analysis, we compared DMO data from people with COPD to a convenience sample of 19 healthy older adults (47% women, mean age 71±6 years) and found that walking speed and cadence varied between participants with COPD and healthy adults (e.g. mean±sd walking speed 0.83±0.12 versus 0.90±0.12 m·s-1, p=0.041).
CONCLUSION: In people with COPD, gait DMOs are normally distributed and worsen as disease advances. Moreover, walking speed and cadence DMOs are significantly altered when compared to healthy peers. Further research should elucidate which DMOs can be improved with treatments to enhance mobility and reduce adverse events.
METHODS: 549 people with COPD from seven European sites and 19 healthy older adults wore single wearable devices (either Axivity AX6 or DynaPort MoveMonitor MM+) continuously for 1 week, from which we identified walking bouts, calculated 15 digital mobility outcomes (DMOs) aggregated at the weekly level, and compared them across COPD severity levels and with healthy peers.
RESULTS: Of the participants with COPD, 37% were female with a mean±sd age of 68±8 years and a post-bronchodilator forced expiratory volume in 1 s of 54±20% predicted. All gait DMOs were normally distributed and exhibited variability between participants (e.g. mean±sd walking speed of 0.83±0.12 m·s-1, ranging from 0.48 to 1.20 m·s-1). Walking speed and cadence DMOs were lower with increasing disease severity (e.g. mean±sd walking speed of 0.88±0.11, 0.85±0.12, 0.80±0.12 and 0.78±0.14 m·s-1 across Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 1 to 4, p<0.001; mean±sd cadence of 93±6, 91±6 and 89±7 steps·min-1 across GOLD A, B and E, p=0.013). Stride length and duration varied across COPD severity levels. Walking speed and cadence bout-to-bout variability only varied across dyspnoea severity levels. In a secondary analysis, we compared DMO data from people with COPD to a convenience sample of 19 healthy older adults (47% women, mean age 71±6 years) and found that walking speed and cadence varied between participants with COPD and healthy adults (e.g. mean±sd walking speed 0.83±0.12 versus 0.90±0.12 m·s-1, p=0.041).
CONCLUSION: In people with COPD, gait DMOs are normally distributed and worsen as disease advances. Moreover, walking speed and cadence DMOs are significantly altered when compared to healthy peers. Further research should elucidate which DMOs can be improved with treatments to enhance mobility and reduce adverse events.