Nature communications · 2026
Recreating viable YYh genotype uncovers the role of CpYYL underlying YY lethality in papaya.
СтатьяНазвание и аннотация: Перевод в очереди
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Yue Jingjing, Liu Juan, Zeng Qiuxia, Wai Ching Man, Deng Ban, Tong Yihan, Zuo Liping, Xiang Tao, Xie Wangyang, Zhao Xiaobing, Lai Juan, Liao Jingjin, Lai Qingqing, Xu Liangwei, Zhu Yating, He Juan, Zhang Mingjing, Nie Suyue, Lin Zeng, Liang Yanqing, Jiang Shaolian, Chen Xi, Wang Bowei, Huang Yongji, Xu Yi, Nguyen-Edquilang Julie, Ma Yaying, Fumia Nathan, Jones Tyler, Quesada-Rojas Patricia, Mora-Newcomer Eric, Zhang Jisen, Yu Qingyi, Wang Ming-Li, Ming Ray
Аннотация
Papaya is a trioecious species with XX females, XY males, and XYh hermaphrodites. Any combination of Y and Yh chromosomes is lethal. The gene underlying YY lethality is pivotal in the transition from stage 2 to stage 3 in sex chromosome evolution. Here, we identify and functionally validate the YY lethality gene in papaya, CpYYL. Loss of CpYYL function accelerates glycolysis and reduces sucrose accumulation in embryo, causing embryo abortion. CpYYL interacts with CpAKRP and overexpression of both genes partially rescues seed abortion in the heterozygous emb506 and akrp mutants, indicating conserved role in plastid differentiation and embryo development. Viable YYh and YhYh plants are generated through genetic engineering and crossing, although both genotypes show high seedling mortality. Crossing YYh male with XX female papaya shows 1:1 ratio of male to hermaphrodite plants without recombination between MSY and HSY. Identification of CpYYL fills a critical gap in papaya sex chromosome evolution, and provides new resources for genomic and epigenetic studies.