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DOI 10.1182/bloodadvances.2023011366

Медицинская библиотека · Blood advances · 2023

Minimum factor VIII levels to prevent joint bleeding in mild hemophilia A.

Luo Yunjiao, Wang Yuhao, Wang Yingxue, Wang Yihan, Yan Na, Shiferaw Blen Dereje, Mackay Louisa Esi, Zhang Ziyang, Zhang Caiyi, Wang Wei

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

PURPOSE: Suicidal mortality is high in rural areas, and suicidal ideation, an early psychology of suicidal behavior, is particularly important for the early prevention and intervention of suicide. This study aimed to establish a nomogram model to predict high-risk groups among rural adolescents who might develop suicidal ideation.

PATIENTS AND

METHODS

This study conducted a cross-sectional survey of 1900 rural secondary school students in Xuzhou, China. The samples were randomly divided into a training set (1330) and a validation set (570), and a nomogram prediction model was constructed using the potential predictors of suicidal ideation screened from the training set using Lasso-Logistic regression. The model was validated using ROC, calibration, and clinical decision curves.

RESULTS

The reported rate of suicidal ideation among rural adolescents is 18.9%. Lasso-Logistic regression found that emotional abuse, emotional neglect, hostility, subjective sleep quality, daytime dysfunction, withdrawal/escape, and depression were significant risk factors for suicidal ideation. A nomogram was built using the above 7 predictors. The area under the ROC curve (AUC) of our predictive model was 0.821 in the training set and 0.765 in the validation set, with corrected C-indices of 0.817 and 0.764, respectively. Furthermore, the calibration curves demonstrated good alignment with the ideal line (P > 0.05), and the decision curve analysis results indicated positive clinical utility.

CONCLUSION

The nomogram model constructed in this study may be an effective tool for predicting suicidal ideation in rural middle school students. It helps identify high-risk groups with suicidal ideation and provides more reliable information for the early prevention and intervention of suicide.

Для цитирования: Luo Yunjiao, Wang Yuhao, Wang Yingxue, Wang Yihan, Yan Na, Shiferaw Blen Dereje, Mackay Louisa Esi, Zhang Ziyang, Zhang Caiyi, Wang Wei. Minimum factor VIII levels to prevent joint bleeding in mild hemophilia A.. Blood advances. 2023. DOI: 10.1182/bloodadvances.2023011366.

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