Doxepin cream for eczema?

One of the more disruptive symptoms of eczema is itching. Traditionally, it is treated with emollients, topical corticosteroids or oral antihistamines. A topical form of the antidepressant doxepin (doxepin 5% cream; Xepin-Bioglan) is now marketed for "the relief of pruritus associated with eczema" in adults and children aged over 12 years. Here, we review the efficacy and safety of this product and assess its role in the management of eczema.