Cancer investigation · 2020
Association between Single Nucleotide Polymorphisms and Glioma Risk: A Systematic Literature Review.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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Tavares Cléciton Braga, Gomes-Braga Francisca das Chagas Sheyla Almeida, Sousa Emerson Brandao, Brito José Nazareno Pearce de Oliveira, Melo Mariella de Almeida, Campelo Viriato, Neto Fidelis Manes, de Araújo Ricardo Marques Lopes, Kessler Iruena Moraes, Sousa Júnior Leonardo de Moura, Filho Luís Carlos Carvalho, Aguiar Yousef Qathaf, Lopes Costa Pedro Vitor, da Silva Benedito Borges
Аннотация
This study aimed to determine the main single nucleotide polymorphisms (SNPs) that are associated with an increased or decreased risk of glioma development in healthy individuals. We conducted a systematic review of the articles published in English on the PUBMED database between January 2008 and December 2017. Our search resulted in a total of 743 articles; however, only 56 were included in this review. A total of 148 polymorphisms were found, which involved 64 different genes. The polymorphisms that were most associated with an increased risk of glioma development were polymorphic variants rs179782, rs13181, and rs3791679 of the genes XRCC1, ERCC2, and EFEMP1, respectively.