[The problem of tissue developmental defects in childhood].

Chronic diseases of the thymus, lungs and kidneys observed in children are viewed basing on analysis of the malformations detected in the children at tissue and cellular structural level, using autopsy and biopsy evidence. Multiple modality investigation was focused on dysplasia, hypoplasia and dyschronism. Dysplasia was characterized by congenital and acquired forms similar in the development and presentation while dyschronism by enhancement or inhibition of structural development seen in immaturity or premature postnatal involution. Immaturity shows the possibility of further development and structural and functional patency. The occurrence of tissue immaturity is not rare, being found in one or many organs of the child. Tissue malformations are chronic inflammation risk factors.