Middle East journal of anaesthesiology · 2010
Pretreatment with remifentanil is associated with less succinylcholine-induced fasciculation.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Nasseri Karim, Arastheh Mehdi Tayebi, Shami Shoaleh
Аннотация
BACKGROUND: Succinylcholine is a popular muscle relaxant and one of its most common side effects is muscle fasciculation. The purpose of this study was to evaluate the efficacy of remifentanil in preventing succinylcholine-induced fasciculation in patients undergoing general anesthesia.
METHODS: In aprospective, double blind study, 60 ASA I & II patients were randomly assigned into two groups (30 each) to receive either remifentanil 1 microg/kg (Group R), or saline 3 ml (Group S) as a pretreatment agent, one minute before induction of general anesthesia by propofol, fentanyl, and 1.5 mg/kg succinylcholine. The duration and the intensity of fasciculation were assessed using a four-point rating scale. Data were analyzed by Mann-Whitney U-test, Fisher exact test and Student-t-test using SPSS software.
RESULTS: In the remifentanil group the duration (p < 0.001) and the intensity (p < 0.001) of fasciculation were lower compared to the saline group. However the incidence of bradycardia was higher in the remifentanil group in comparison to the group which received normal saline.
CONCLUSIONS: Our findings indicate that remifentanil can reduce the duration and the intensity of succinylcholine induced fasciculation. However, it induces greater bradycardia.
METHODS: In aprospective, double blind study, 60 ASA I & II patients were randomly assigned into two groups (30 each) to receive either remifentanil 1 microg/kg (Group R), or saline 3 ml (Group S) as a pretreatment agent, one minute before induction of general anesthesia by propofol, fentanyl, and 1.5 mg/kg succinylcholine. The duration and the intensity of fasciculation were assessed using a four-point rating scale. Data were analyzed by Mann-Whitney U-test, Fisher exact test and Student-t-test using SPSS software.
RESULTS: In the remifentanil group the duration (p < 0.001) and the intensity (p < 0.001) of fasciculation were lower compared to the saline group. However the incidence of bradycardia was higher in the remifentanil group in comparison to the group which received normal saline.
CONCLUSIONS: Our findings indicate that remifentanil can reduce the duration and the intensity of succinylcholine induced fasciculation. However, it induces greater bradycardia.
Предметные рубрики MeSH
AdultAnesthesia, GeneralAnesthetics, CombinedAnesthetics, IntravenousBradycardiaDouble-Blind MethodFasciculationFemaleFentanylHumansMaleMiddle AgedNeuromuscular Depolarizing AgentsPiperidinesPropofolProspective StudiesRemifentanilSeverity of Illness IndexStatistics, NonparametricSuccinylcholineYoung Adult