European eating disorders review : the journal of the Eating Disorders Association · 2025
Prefrontal Cortex Recruitment to Food Stimuli Differs in Overweight/Obesity and Binge Eating Disorder.
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Svaldi Jennifer, Schopp Betti, Schroeder Philipp A, Werle Dustin, Ehlis Ann-Christine
Аннотация
BACKGROUND: At a phenotypical level, the repeated occurrence of binge eating episodes clearly differentiates individuals with binge eating disorder (BED) from individuals with overweight but without BED. Their neural profiles during food-related inhibition, however, indicate prefrontal hypoactivation in both groups. The present study investigated differential neural activations in upper lateral (right dorsolateral prefrontal cortex [DLPFC]) and inferior (right inferior frontal gyrus [IFG]) control regions during food-related inhibition by functional near-infrared spectroscopy (fNIRS). In addition, activity in reward-related brain regions (orbitofrontal cortex [OFC]) during stimulus processing was measured.
METHOD: Individuals with BED (n = 32), a control group of individuals with overweight and without BED (OWC, n = 21), and a control group of individuals with normal weight and without BED (NWC; n = 31) underwent a Go/No-Go (GNG) and a stimulus degradation task during fNIRS, both with food and non-food stimuli in counterbalanced order.
RESULTS: Most predicted outcomes were not significant. Neural recordings during GNG underscore prefrontal hypoactivation in both BED and OWC relative to NWC, however, with differential alterations: In the Food-NoGo condition, the BED group displayed hypoactivation in the IFG, while the OWC showed hypoactivation in the DLPFC.
CONCLUSIONS: The results suggest differential requirements for DLPFC and IFG recruitment during food-related inhibition in individuals with BED and overweight.
METHOD: Individuals with BED (n = 32), a control group of individuals with overweight and without BED (OWC, n = 21), and a control group of individuals with normal weight and without BED (NWC; n = 31) underwent a Go/No-Go (GNG) and a stimulus degradation task during fNIRS, both with food and non-food stimuli in counterbalanced order.
RESULTS: Most predicted outcomes were not significant. Neural recordings during GNG underscore prefrontal hypoactivation in both BED and OWC relative to NWC, however, with differential alterations: In the Food-NoGo condition, the BED group displayed hypoactivation in the IFG, while the OWC showed hypoactivation in the DLPFC.
CONCLUSIONS: The results suggest differential requirements for DLPFC and IFG recruitment during food-related inhibition in individuals with BED and overweight.