Advances in experimental medicine and biology · 2026
Brain Hydration Correlates with Cerebral Oxygen Saturation in Perilesional Foci in Moderate Traumatic Brain Injury.
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Trofimov Alex O, Kivenko Anastasia, Volkova Ekaterina, Nemoto Edwin M, Bragina Olga, Bragin Denis E
Аннотация
PURPOSE: The uncoupling of cerebral oxygenation is interconnected with brain hydration dynamics and is essential for understanding the characteristics of intracerebral hemorrhage pathomorphosis. The aim was to study the brain hydration and cerebral oxygen saturation status changes in perilesional penumbra foci (PPF) in moderate isolated traumatic brain injury (moiTBI) patients.
MATERIALS AND METHODS: Seventy-seven moiTBI patients (women 35 and men 42, median age 37 years) with unilateral lesions (Marshall Score II-III) were included in this study. Net water uptake was measured in PPF using non-contrast computed tomography (NCCT) 2 days after admission. NWU in hypoattenuated zones of PPF was calculated using NCCT. Cerebral oxygen saturation (SctO2) was measured in the frontal lobes. Data are shown as a median [interquartile range]. Statistical analysis was performed using nonparametric statistics.
RESULTS: In PPF, SctO2 was 64.03% [60.1;67.0], and NWU was 4.98% [2.21;7.39]. Increased NWU values in PPF were significantly inversely correlated with SctO2 (r = -0.608, p < 0.001).
CONCLUSIONS: Brain edema parameters in PPF were significantly associated with cerebral O2 saturation disturbances in moiTBI.
MATERIALS AND METHODS: Seventy-seven moiTBI patients (women 35 and men 42, median age 37 years) with unilateral lesions (Marshall Score II-III) were included in this study. Net water uptake was measured in PPF using non-contrast computed tomography (NCCT) 2 days after admission. NWU in hypoattenuated zones of PPF was calculated using NCCT. Cerebral oxygen saturation (SctO2) was measured in the frontal lobes. Data are shown as a median [interquartile range]. Statistical analysis was performed using nonparametric statistics.
RESULTS: In PPF, SctO2 was 64.03% [60.1;67.0], and NWU was 4.98% [2.21;7.39]. Increased NWU values in PPF were significantly inversely correlated with SctO2 (r = -0.608, p < 0.001).
CONCLUSIONS: Brain edema parameters in PPF were significantly associated with cerebral O2 saturation disturbances in moiTBI.