Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2011
Controlled ovarian hyperstimulation in women with polycystic ovarian syndrome with or without intrauterine insemination.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Wiser Amir, Shalom-Paz Einat, Reinblatt Shaune Leigh, Holzer Hananel, Tulandi Togas
Аннотация
OBJECTIVE: To evaluate the value of intrauterine insemination (IUI) in controlled ovarian hyperstimulation (COH) among couples with polycystic ovary syndrome (PCOS) and normal semen analysis.
DESIGN: Retrospective cohort study.
SETTING: University teaching center.
PATIENTS: PCOS couples with normal semen analysis that underwent COH with IUI or timed intercourse (TIC).
INTERVENTION: COH with clomiphene citrate, letrozole or gonadotropins with or without IUI.
MAIN OUTCOME MEASURES: Clinical pregnancy rates.
RESULTS: Of a total 265 cycles, 151 cycles were with IUI and 114 others with TIC. No significant difference was found in the overall pregnancy rates between the TIC group (17.5%) and the IUI group (16.6%). Analysis of pregnancy rates according to the type of COH treatments did not demonstrate the advantages of IUI over TIC.
CONCLUSION: Compared to timed intercourse, IUI does not increase the pregnancy rate in couples with PCOS and normal semen analysis treated with COH.
DESIGN: Retrospective cohort study.
SETTING: University teaching center.
PATIENTS: PCOS couples with normal semen analysis that underwent COH with IUI or timed intercourse (TIC).
INTERVENTION: COH with clomiphene citrate, letrozole or gonadotropins with or without IUI.
MAIN OUTCOME MEASURES: Clinical pregnancy rates.
RESULTS: Of a total 265 cycles, 151 cycles were with IUI and 114 others with TIC. No significant difference was found in the overall pregnancy rates between the TIC group (17.5%) and the IUI group (16.6%). Analysis of pregnancy rates according to the type of COH treatments did not demonstrate the advantages of IUI over TIC.
CONCLUSION: Compared to timed intercourse, IUI does not increase the pregnancy rate in couples with PCOS and normal semen analysis treated with COH.
Предметные рубрики MeSH
AdultAromatase InhibitorsClomipheneCohort StudiesFemaleFertility Agents, FemaleGonadotropinsHumansInfertility, FemaleInsemination, ArtificialLetrozoleNitrilesOvarian Hyperstimulation SyndromeOvulation InductionPolycystic Ovary SyndromePregnancyPregnancy RateQuebecRetrospective StudiesSelective Estrogen Receptor ModulatorsSexual BehaviorTriazoles