Controlled ovarian hyperstimulation in women with polycystic ovarian syndrome with or without intrauterine insemination.

OBJECTIVE

To evaluate the value of intrauterine insemination (IUI) in controlled ovarian hyperstimulation (COH) among couples with polycystic ovary syndrome (PCOS) and normal semen analysis.

DESIGN

Retrospective cohort study.

SETTING

University teaching center.

PATIENTS: PCOS couples with normal semen analysis that underwent COH with IUI or timed intercourse (TIC).

INTERVENTION: COH with clomiphene citrate, letrozole or gonadotropins with or without IUI.

MAIN OUTCOME MEASURES: Clinical pregnancy rates.

RESULTS

Of a total 265 cycles, 151 cycles were with IUI and 114 others with TIC. No significant difference was found in the overall pregnancy rates between the TIC group (17.5%) and the IUI group (16.6%). Analysis of pregnancy rates according to the type of COH treatments did not demonstrate the advantages of IUI over TIC.

CONCLUSION

Compared to timed intercourse, IUI does not increase the pregnancy rate in couples with PCOS and normal semen analysis treated with COH.