Bulletin of experimental biology and medicine · 2026
Comparative Characteristics of Morphometric Changes in the Brain Tissue Caused by Prenatal Alcohol Exposure and Hypoxia.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Shumilova S N, Solonsky A V, Potapov A V, Logvinov S V, Bokhan N A, Mandel A I, Makhmutkhodzhaev A Sh, Varakuta E Y, Mustafina L R, Zhdankina A A, Gerasimov A V, Kostyuchenko V P, Maksimova K Y, Bulatskaya E Y
Аннотация
According to current knowledge, hypoxia is a key mechanism mediating the detrimental effects of prenatal alcohol exposure on the nervous tissue. However, comparative analysis of these interrelated conditions has only been partially addressed. We conducted a morphometric analysis of fetal brain tissue affected by chronic alcohol exposure and hypoxia. A decrease in the specific area of neuroblasts, glioblasts, and microvascular elements was found. Hypoxia promoted enlargement of neuroblasts and their differentiation into immature neurons, whereas alcohol exposure led only to a decrease in their number. In the brain subjected to hypoxia, glioblasts were characterized by size variability with a general trend toward reduction, while alcohol had no significant effect on their size. Both experimental groups showed a decline in vascular density.