Archives of otolaryngology--head & neck surgery · 2002
The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract: friend or foe?
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Rahbar Reza, Jones Dwight T, Nuss Roger C, Roberson David W, Kenna Margaret A, McGill Trevor J, Healy Gerald B
Аннотация
OBJECTIVE: To evaluate the role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract.
DESIGN: Prospective study; institutional review board-approved clinical trial.
SETTING: Tertiary care pediatric medical center.
PATIENTS: Fifteen patients; choanal atresia in 5 patients, airway stenosis in 8 patients, hypopharyngeal stenosis in 1 patient, and esophageal stenosis in 1 patient.
OUTCOME: The efficacy and safety of mitomycin in the prevention of scar formation.
INTERVENTION: All patients underwent surgical repair of the stenotic area, followed by topical application of mitomycin (1 mL of 0.4 mg/mL) for 4 minutes.
RESULTS: Ten patients (67%) showed major improvement, 4 patients (27%) showed minor improvement, and 1 patient (7%) showed no improvement.
CONCLUSION: Topical application of mitomycin can play an effective role in the prevention and treatment of scar formation in the aerodigestive tract.
DESIGN: Prospective study; institutional review board-approved clinical trial.
SETTING: Tertiary care pediatric medical center.
PATIENTS: Fifteen patients; choanal atresia in 5 patients, airway stenosis in 8 patients, hypopharyngeal stenosis in 1 patient, and esophageal stenosis in 1 patient.
OUTCOME: The efficacy and safety of mitomycin in the prevention of scar formation.
INTERVENTION: All patients underwent surgical repair of the stenotic area, followed by topical application of mitomycin (1 mL of 0.4 mg/mL) for 4 minutes.
RESULTS: Ten patients (67%) showed major improvement, 4 patients (27%) showed minor improvement, and 1 patient (7%) showed no improvement.
CONCLUSION: Topical application of mitomycin can play an effective role in the prevention and treatment of scar formation in the aerodigestive tract.